Basic Study
Copyright ©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Oncol. Jun 15, 2025; 17(6): 105664
Published online Jun 15, 2025. doi: 10.4251/wjgo.v17.i6.105664
RPF2 regulates the protein kinase B/mammalian target of rapamycin pathway in the pathogenesis of Helicobacter pylori
Yan-Qiao Hua, Kai-Xin Guo, Peng Ni, Di Wang, Tong-Yan An, Yang-Ye Gao, Rong-Guang Zhang
Yan-Qiao Hua, Kai-Xin Guo, Peng Ni, Di Wang, Tong-Yan An, Yang-Ye Gao, Rong-Guang Zhang, Department of Epidemiology, College of Public Health, Zhengzhou University, Zhengzhou 450001, Henan Province, China
Kai-Xin Guo, Department of Occupational Disease Control, Anyang Center for Disease Control and Prevention, Anyang 455000, Henan Province, China
Rong-Guang Zhang, Heinz Mehhorn Academician Workstation, School of Public Health, Hainan Medical University, Haikou 571199, Hainan Province, China
Author contributions: Hua YQ, Ni P and Zhang RG designed the research study; Hua YQ, Guo KX, Wang D, An TY and Gao YY performed experiments; Hua YQ and Guo KX analyzed the data; Hua YQ and Zhang RG wrote the manuscript; All authors have read and approved the final manuscript.
Supported by the National Natural Science Foundation of China, No. 82160634.
Institutional review board statement: The study was conducted in vitro and did not involve human subjects.
Institutional animal care and use committee statement: The study was conducted in vitro and did not involve any animal subjects.
Conflict-of-interest statement: The authors declare that they have no conflict of interest.
Data sharing statement: The experimental data that support the findings of this study are available from the corresponding author at zrg@zzu.edu.cn.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Rong-Guang Zhang, MD, Professor, Department of Epidemiology, College of Public Health, Zhengzhou University, No. 100 Science Avenue, Zhongyuan District, Zhengzhou 450001, Henan Province, China. zrg@zzu.edu.cn
Received: February 10, 2025
Revised: March 25, 2025
Accepted: May 12, 2025
Published online: June 15, 2025
Processing time: 124 Days and 17.3 Hours
Core Tip

Core Tip: Helicobacter pylori (H. pylori) has a profound impact on gastric cancer development. RPF2 is overexpressed in cancer and can enhance cancer cell proliferation. However, the mechanism of RPF2 in the pathogenesis of H. pylori infection remains largely unknown. We found that H. pylori infection increased RPF2 expression, affecting the malignant behavior of gastric epithelial cells by regulating the protein kinase B/mammalian target of rapamycin pathway. This study is the first to explore the mechanism of RPF2 in the pathogenesis of H. pylori infection.