Wang L, Wang MH, Yuan YH, Xu RZ, Bai L, Wang MZ. Identification and validation of extracellular matrix-related genes in the progression of gastric cancer with intestinal metaplasia. World J Gastrointest Oncol 2025; 17(6): 105160 [DOI: 10.4251/wjgo.v17.i6.105160]
Corresponding Author of This Article
Mi-Zhu Wang, MD, Chief Physician, Department of Gastroenterology, The Second Affiliated Hospital of Baotou Medical College, No. 30 Hude Mulin Street, Qingshan District, Baotou 300000, Inner Mongolia Autonomous Region, China. wangmizhu2008@163.com
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Basic Study
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Gastrointest Oncol. Jun 15, 2025; 17(6): 105160 Published online Jun 15, 2025. doi: 10.4251/wjgo.v17.i6.105160
Identification and validation of extracellular matrix-related genes in the progression of gastric cancer with intestinal metaplasia
Lu Wang, Meng-Han Wang, Yao-Hong Yuan, Rui-Ze Xu, Lu Bai, Mi-Zhu Wang
Lu Wang, Lu Bai, Department of Gastroenterology, The Second Affiliated Hospital of Baotou Medical College, Baotou Medical College, Baotou 300000, Inner Mongolia Autonomous Region, China
Meng-Han Wang, Yao-Hong Yuan, Rui-Ze Xu, Baotou Medical College, Baotou 300000, Inner Mongolia Autonomous Region, China
Mi-Zhu Wang, Department of Gastroenterology, The Second Affiliated Hospital of Baotou Medical College, Baotou 300000, Inner Mongolia Autonomous Region, China
Co-first authors: Lu Wang and Meng-Han Wang.
Author contributions: Wang L, Wang MH and Yuan YH designed the research study and completed the analysis; Xu RZ and Bai L completed the specimen collection and experimental process; Wang MZ completed the manuscript review and revisions; All authors read and approved the final manuscript.
Supported by the Inner Mongolia Autonomous Region Health Science and Technology Program, No. 202201441; and Qingmiao Plan of Baotou Medical College, No. BYJJ-ZRQM202230.
Institutional review board statement: The study was reviewed and approved by the local Ethics Committee of The Second Affiliated Hospital of Baotou Medical College (Approval No. 2024-ZX-057).
Institutional animal care and use committee statement: This study does not involve any animal experiments.
Conflict-of-interest statement: The authors declare that they have no conflicts of interest.
Data sharing statement: The datasets supporting this research include GSE191275, GSE15459 and the Cancer Genome Atlas-stomach adenocarcinoma dataset. GSE191275 and GSE15459 are available from the Gene Expression Omnibus database (https://www.ncbi.nlm.nih.gov/geo); The Cancer Genome Atlas-stomach adenocarcinoma is available from the Cancer Genome Atlas database (https://www.cancer.gov/ccg/research/genome-sequencing/tcga).
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Mi-Zhu Wang, MD, Chief Physician, Department of Gastroenterology, The Second Affiliated Hospital of Baotou Medical College, No. 30 Hude Mulin Street, Qingshan District, Baotou 300000, Inner Mongolia Autonomous Region, China. wangmizhu2008@163.com
Received: January 14, 2025 Revised: March 31, 2025 Accepted: April 23, 2025 Published online: June 15, 2025 Processing time: 151 Days and 8.5 Hours
Core Tip
Core Tip: This study aimed to identify molecular biomarkers for predicting gastric cancer (GC) risk and monitoring intestinal metaplasia progression. Using weighted gene co-expression network analysis, 71 upregulated and 171 downregulated genes related to the extracellular matrix were identified. Secreted protein acidic and rich in cysteine (SPARC) and SERPINE1 were found to be significant prognostic genes. A survival model integrating clinical tumor node metastasis staging, age, and SPARC/SERPINE1 expression was developed. Immunohistochemistry and western blot analyses confirmed the elevated expression of SPARC in intestinal metaplasia and GC. SPA0RC expression correlated with cancer progression and could serve as an early biomarker and therapeutic target for GC.
