Basic Study
Copyright ©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Oncol. Jun 15, 2025; 17(6): 105016
Published online Jun 15, 2025. doi: 10.4251/wjgo.v17.i6.105016
Role and mechanism of sarcosine dehydrogenase in the progression of gallbladder cancer through chemokine pathways
Zhen Gao, Xin Zhang, Hua He
Zhen Gao, Hua He, Department of General Surgery, Qingpu Branch of Zhongshan Hospital, Fudan University, Shanghai 201700, China
Xin Zhang, Department of Hepatobiliary Surgery, Pudong Hospital, Fudan University, Shanghai 200433, China
Co-first authors: Zhen Gao and Xin Zhang.
Author contributions: Gao Z and Zhang X contributed equally to this work; Gao Z designed the study, collected data, and drafted the manuscript; Zhang X conducted data analysis, performed statistical interpretation, and assisted with manuscript revisions; He H supervised the study, provided critical guidance, and contributed to the final manuscript editing; All authors have reviewed and approved the final version.
Supported by the Qingpu Science and Technology Commission Project, No. QKY2022-13.
Institutional review board statement: This study was conducted solely on commercially available cell lines and did not involve human participants, identifiable personal data, or the use of experimental animals. Therefore, the research was exempt from institutional review board approval.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Data sharing statement: All data generated or analyzed during this study are included in this published article. Further details can be provided upon reasonable request from the corresponding author at hehua-sh@21cn.com.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Hua He, Department of General Surgery, Qingpu Branch of Zhongshan Hospital, Fudan University, No. 1158 Park Road East, Qingpu District, Shanghai 201700, China. hehua-sh@21cn.com
Received: February 7, 2025
Revised: March 10, 2025
Accepted: April 24, 2025
Published online: June 15, 2025
Processing time: 126 Days and 4.5 Hours
Core Tip

Core Tip: In this study, we examined the roles of sarcosine dehydrogenase (SARDH) and C-X-C motif chemokine ligand 1 (CXCL1) in cancer cells and their effects on key signaling pathways. SARDH silencing enhanced cell proliferation, whereas CXCL1 silencing suppressed migration and invasion, triggering protein kinase B and extracellular signal-regulated kinase signaling pathways. These findings highlight SARDH and CXCL1 as critical regulators of tumor cell behavior and offer new insights into developing targeted cancer therapies.