Identification of key hub genes associated with anti-gastric cancer effects of lotus plumule based on machine learning algorithms

doi:10.4251/wjgo.v17.i4.103048

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Apr 15, 2025 (publication date) through Mar 25, 2025

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World Journal of Gastrointestinal Oncology

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1948-5204

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Basic Study

World J Gastrointest Oncol. Apr 15, 2025; 17(4): 103048
Published online Apr 15, 2025. doi: 10.4251/wjgo.v17.i4.103048

Identification of key hub genes associated with anti-gastric cancer effects of lotus plumule based on machine learning algorithms

Fan-Di Meng, Shu-Min Jia, Yu-Bin Ma, Yu-Hua Du, Wen-Jing Liu, Yi Yang, Ling Yuan, Yi Nan

Fan-Di Meng, Shu-Min Jia, Yu-Bin Ma, Yi Nan, Traditional Chinese Medicine College, Ningxia Medical University, Yinchuan 750004, Ningxia Hui Autonomous Region, China

Yu-Hua Du, Yi Yang, Ling Yuan, College of Pharmacy, Ningxia Medical University, Yinchuan 750004, Ningxia Hui Autonomous Region, China

Wen-Jing Liu, Key Laboratory of Hui Ethnic Medicine Modernization of Ministry of Education, Ningxia Medical University, Yinchuan 750004, Ningxia Hui Autonomous Region, China

Co-corresponding authors: Ling Yuan and Yi Nan.

Author contributions: Meng FD, Yuan L, and Nan Y designed the study; Meng FD, Jia SM, Ma YB, and Du YH collected the data; Liu WJ, Yang Y, Yuan L, and Nan Y conducted data visualization; Meng FD, Ma YB, Liu WJ, and Yuan L analyzed the data and wrote the manuscript; Yuan L and Nan Y provided funding, and they contributed equally to this work as co-corresponding authors.

Supported by Ningxia Key Research and Development Program, No. 2023BEG02015; and Talent Development Projects of Young Qihuang of National Administration of Traditional Chinese Medicine (2020).

Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.

Data sharing statement: No additional data are available.

Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/

Corresponding author: Yi Nan, Traditional Chinese Medicine College, Ningxia Medical University, No.1160 Shengli Street, Xingqing District, Yinchuan 750004, Ningxia Hui Autonomous Region, China. 20080011@nxmu.edu.cn

Received: November 7, 2024
Revised: December 11, 2024
Accepted: January 16, 2025
Published online: April 15, 2025
Processing time: 139 Days and 10 Hours

Core Tip

Core Tip: Lotus plumule exhibits promising efficacy in the prevention and treatment of gastric cancer. This extensive study has identified four pivotal hub genes associated with the anti-gastric cancer effects of lotus plumule and elucidated the upstream and downstream targets of one of these genes, which possess significant potential as novel therapeutic and diagnostic targets for gastric cancer. These findings offer groundbreaking and innovative insights into the clinical management of gastric cancer, potentially enhancing its treatment and facilitating early detection.