Case Control Study
Copyright ©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Oncol. Apr 15, 2025; 17(4): 102584
Published online Apr 15, 2025. doi: 10.4251/wjgo.v17.i4.102584
Investigation of high-mobility group box 1 variants with lymph node status and colorectal cancer risk
Xin Liu, Sheng Zhang, Hao Qiu, Zhi-Qiang Xie, Wei-Feng Tang, Yu Chen, Xi Wei
Xin Liu, Sheng Zhang, Department of General Surgery, Changzhou Third People’s Hospital, Changzhou 213001, Jiangsu Province, China
Hao Qiu, Laboratory Medicine, School of Medicine, Jiangsu University, Zhenjiang 212000, Jiangsu Province, China
Zhi-Qiang Xie, Department of Clinical Laboratory, Fujian Medical University Union Hospital, Fuzhou 350001, Fujian Province, China
Wei-Feng Tang, Department of Cardiothoracic Surgery, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing 210000, Jiangsu Province, China
Yu Chen, Department of Medical Oncology, Fujian Cancer Hospital and Fujian Medical University Cancer Hospital, Fuqing 350014, Fujian Province, China
Xi Wei, Department of Pathology, Affiliated People’s Hospital of Jiangsu University, Zhenjiang 212002, Jiangsu Province, China
Author contributions: Zhang S designed the research study; Liu X, Zhang S, Qiu H, Xie ZQ, Tang WF, and Chen Y performed the research; Liu X, Wei X and Zhang S contributed new reagents and analytic tools; Liu X, Zhang S and Wei X analyzed the data and wrote the manuscript; All authors have read and approve the final manuscript.
Supported by the Major Project of Changzhou Science and Technology Bureau, No. CJ20220255.
Institutional review board statement: Fujian Medical University Ethics Review Committee approved the present study (No. KT2018-003-01).
Informed consent statement: Each subject signed an informed consent.
Conflict-of-interest statement: The authors declare that they have no conflict of interest.
STROBE statement: The authors have read the STROBE Statement-a checklist of items, and the manuscript was prepared and revised according to the STROBE Statement-a checklist of items.
Data sharing statement: Additional data are available in Supplementary Table 1.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Sheng Zhang, Department of General Surgery, Changzhou Third People’s Hospital, No. 300 Lanling North Road, Changzhou 213001, Jiangsu Province, China. 13601507172@163.com
Received: October 24, 2024
Revised: December 31, 2024
Accepted: January 22, 2025
Published online: April 15, 2025
Processing time: 152 Days and 24 Hours
Core Tip

Core Tip: To our knowledge, this study highlights a possible association between high-mobility group box 1 (HMGB1) rs1412125 polymorphism and the increased risk of colorectal cancer (CRC). In the future, more studies should be conducted to explore HMGB1 rs1412125 polymorphism in relation to CRC development.