Gastric cancer in patients with Helicobacter pylori-negative autoimmune gastritis

doi:10.4251/wjgo.v17.i4.101661

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Apr 15, 2025 (publication date) through Mar 25, 2025

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World Journal of Gastrointestinal Oncology

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1948-5204

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastrointest Oncol. Apr 15, 2025; 17(4): 101661
Published online Apr 15, 2025. doi: 10.4251/wjgo.v17.i4.101661

Gastric cancer in patients with Helicobacter pylori-negative autoimmune gastritis

Hiroshi Kishikawa, Jiro Nishida

Hiroshi Kishikawa, Jiro Nishida, Department of Gastroenterology, Ichikawa General Hospital, Tokyo Dental College, Ichikawa 272-8513, Chiba, Japan

Author contributions: Kishikawa H contributed to the conception, design, and drafting of the article; Nishida J contributed to editing and supervising this study; All authors have approved the final draft submitted.

Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.

Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/

Corresponding author: Hiroshi Kishikawa, MD, PhD, Associate Professor, Department of Gastroenterology, Ichikawa General Hospital, Tokyo Dental College, 5-11-13 Sugano, Ichikawa 272-8513, Chiba, Japan. kisikawa@tdc.ac.jp

Received: September 23, 2024
Revised: January 6, 2025
Accepted: January 20, 2025
Published online: April 15, 2025
Processing time: 183 Days and 10 Hours

Core Tip

Core Tip: Although in cases of autoimmune gastritis, Helicobacter pylori (H. pylori) is often implicated in gastric cancer development, there are reports of gastric cancer in patients with H. pylori-negative cases. Pathological factors for the development of gastric cancer in H. pylori-negative autoimmune gastritis include severe atrophy, hypergastrinemia, bile reflux, and low acidity. In the diagnosis of H. pylori infection in autoimmune gastritis, it is difficult to accurately diagnose cases of previous infection. When current H. pylori infection is ruled out in autoimmune gastritis sparing antrum, the patient is considered H. pylori-negative; however, this should be re-evaluated in the future.