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©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Oncol. Apr 15, 2025; 17(4): 100484
Published online Apr 15, 2025. doi: 10.4251/wjgo.v17.i4.100484
Published online Apr 15, 2025. doi: 10.4251/wjgo.v17.i4.100484
Natural products and cancer: The urgent need to bridge the gap between preclinical and clinical research
Armando Rojas, Ileana González, Biomedical Research Laboratories, Faculty of Medicine, Catholic University of Maule, Talca 34600000, Chile
Miguel Angel Morales, Molecular and Clinical Pharmacology Program, Institute of Biomedical Sciences, University of Chile, Santiago 8320000, Chile
Author contributions: Rojas A, González I, and Morales MA, contributed to discussion and design of the manuscript, writing, and editing the manuscript, and review of literature; Rojas A, designed the overall concept and outline of the manuscript.
Conflict-of-interest statement: The authors declare that they have no conflict of interest.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Armando Rojas, PhD, Full Professor, Senior Researcher, Biomedical Research Laboratories, Faculty of Medicine, Catholic University of Maule, 3605 San Miguel Ave, Talca 34600000, Chile. arojasr@ucm.cl
Received: August 17, 2024
Revised: January 20, 2025
Accepted: January 27, 2025
Published online: April 15, 2025
Processing time: 219 Days and 19.4 Hours
Revised: January 20, 2025
Accepted: January 27, 2025
Published online: April 15, 2025
Processing time: 219 Days and 19.4 Hours
Core Tip
Core Tip: Natural products have been extensively investigated for their anticancer potential for many decades, and some are milestones in the history of anticancer drug discovery. However, despite the compelling data achieved by preclinical studies, the challenges to validate the clinical use remain ahead.