Prospective Study
Copyright ©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Oncol. Mar 15, 2025; 17(3): 102604
Published online Mar 15, 2025. doi: 10.4251/wjgo.v17.i3.102604
Stoma related complications: A registry study based on a prospective registration system
Nan Chen, Jie Zhang, Lin Wang, Qian Yang, Ai-Wen Wu
Nan Chen, Jie Zhang, Lin Wang, Qian Yang, Ai-Wen Wu, Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Gastrointestinal Center, Unit III, Peking University Cancer Hospital and Institute, Beijing 100142, China
Co-first authors: Nan Chen and Jie Zhang.
Author contributions: Chen N and Zhang J contribute equally to this study as co-first authors; Wu AW designed the research study; Chen N, Zhang J performed the data collection, analysis and manuscript drafting; Yang Q performed the revision and patients’ follow-up; Wang L helped the revision of the manuscript.
Supported by Beijing Municipal Administration of Hospitals Incubating Program, No. PZ2020027; 2018 Beijing Talent Incubating Funding, No. 2018-4; National Natural Science Foundation of China, No. 81773214; Beijing Hospitals Authority Clinical Medicine Development of Special Funding Support, No. ZYLX202116; the National Key R&D Program of China, No. 2021YFF1201104; and Science Foundation of Peking University Cancer Hospital-2023, No. JC202310.
Institutional review board statement: The study was reviewed and approved by The Ethics Committee of Beijing Cancer Hospital (Approval No. 2024KT112).
Clinical trial registration statement: Although this study prospectively collected data and has been categorized as a prospective study, due to time constraints, we were unable to complete the registration process for a clinical trial, which involves multiple steps. Given that this study is observational in nature, we apply for a waiver from clinical trial registration despite having obtained ethical approval.
Informed consent statement: All study participants, or their legal guardian, provided informed written consent prior to study enrollment.
Conflict-of-interest statement: There are no conflicts of interest among the authors.
CONSORT 2010 statement: The authors have read the CONSORT 2010 Statement, and the manuscript was prepared and revised according to the CONSORT 2010 Statement.
Data sharing statement: No additional data are available.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Ai-Wen Wu, MD, PhD, Professor, Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Gastrointestinal Center, Unit III, Peking University Cancer Hospital and Institute, No. 52 Fucheng Road, Haidian District, Beijing 100142, China. wuaw@sina.com
Received: November 13, 2024
Revised: December 22, 2024
Accepted: January 3, 2025
Published online: March 15, 2025
Processing time: 93 Days and 2.8 Hours
Core Tip

Core Tip: Among 734 colorectal cancer patients with stomas, 12.3% experienced stoma related complications, among which mucocutaneous separation, edema, and skin excoriation were the most common ones. The majority of complications were low grade (grade 1-2) by Clavien-Dindo classification. Key risk factors included surgical factors (blood loss > 500 mL, open surgery), stoma features (stoma location, shape, color, height and edema), and body mass index > 30 kg/m², emphasizing the need for comprehensive stoma management.