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©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Oncol. Mar 15, 2025; 17(3): 102083
Published online Mar 15, 2025. doi: 10.4251/wjgo.v17.i3.102083
Published online Mar 15, 2025. doi: 10.4251/wjgo.v17.i3.102083
IL-22/IL-22R1 pathway enhances cholangiocarcinoma progression via ERK1/2 activation
Jin Zhou, Jing-Rui Chen, Jin-Ming Li, Shuang-Qing Han, Xi-Yue Deng, Wen Tong, Chao Wang, The First Central Clinical School, Tianjin Medical University, Tianjin 300192, China
Zhong-Min Li, Department of Hepatobiliary and Pancreatic Surgery, Tianjin Nankai Hospital, Tianjin 300070, China
Yi Bai, Ya-Min Zhang, Department of Hepatobiliary Surgery, Tianjin First Central Hospital, Tianjin 300070, China
Co-first authors: Jin Zhou and Jing-Rui Chen.
Co-corresponding authors: Yi Bai and Ya-Min Zhang.
Author contributions: Zhou J Chen JR made equal contributions to this research as co-firsts; Bai Y and Zhang YM contribute equally to this research as co-corresponding authors; Zhou J, Bai Y and Zhang YM were involved in designing the study; Zhou J, Chen JR, Li JM, Han SQ, Deng XY contributed to the bioinformatics analysis, experimental operation and data analysis; Li ZM, Tong W, Wang C participated in data analysis; Zhou J, Chen JR wrote the manuscript; Bai Y and Zhang YM critically revised the manuscript for important intellectual content; all authors read and approved the final version.
Supported by National Natural Science Foundation of China, No. 82372194.
Institutional review board statement: The research was sanctioned by the Ethics Committee of Tianjin First Central Hospital.
Institutional animal care and use committee statement: Animals experiments were approved by Animal Ethics Committee of Tianjin First Central Hospital.
Conflict-of-interest statement: The authors declare that they have no competing interests.
ARRIVE guidelines statement: The authors have read the ARRIVE guidelines, and the manuscript was prepared and revised according to the ARRIVE guidelines.
Data sharing statement:
The data sources are included in the Methods section of this article. Further information is available from the corresponding author.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Ya-Min Zhang, Chief Physician, PhD, Department of Hepatobiliary Surgery, Tianjin First Central Hospital, No. 24 Fukang Road, Nankai District, Tianjin 300070, China. zhangyamin@nankai.edu.cn
Received: October 8, 2024
Revised: December 16, 2024
Accepted: January 8, 2025
Published online: March 15, 2025
Processing time: 129 Days and 7.5 Hours
Revised: December 16, 2024
Accepted: January 8, 2025
Published online: March 15, 2025
Processing time: 129 Days and 7.5 Hours
Core Tip
Core Tip: This research results show that IL-22R1 is highly expressed in cholangiocarcinoma (CCA) cell lines and tissues. The binding of IL-22 to IL-22R1 forms the IL-22/IL-22R1 axis, which can promote the progression of CCA both in vivo and in vitro. The application of ERK1/2 inhibitors can reverse the promoting effect of IL-22 on CCA, providing potential therapeutic strategies for CCA’s clinical treatment.