Basic Study
Copyright ©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Oncol. Mar 15, 2025; 17(3): 101991
Published online Mar 15, 2025. doi: 10.4251/wjgo.v17.i3.101991
Irreversible electroporation combined with anti-programmed cell death protein 1 therapy promotes tumor antigen-specific CD8+ T cell response
Yang-Yang Ma, Xiao-Hua Wang, Jian-Ying Zeng, Ji-Bing Chen, Li-Zhi Niu
Yang-Yang Ma, Xiao-Hua Wang, Jian-Ying Zeng, Ji-Bing Chen, Central Laboratory, Guangzhou Fuda Cancer Hospital, Guangzhou 510665, Guangdong Province, China
Li-Zhi Niu, Department of Oncology, Guangzhou Fuda Cancer Hospital, Guangzhou 510665, Guangdong Province, China
Author contributions: Ma YY wrote the paper; Wang XH and Zeng JY performed the study selection; Chen JB analyzed the data; Niu LZ designed the project and edited the manuscript; All authors reviewed the final manuscript.
Supported by Science and Technology Program of Guangzhou, No. 202102010077; and International Science Foundation of Guangzhou Fuda Cancer Hospital, No. Y2020-ZD-03.
Institutional animal care and use committee statement: This animal experiment was examined and approved by the laboratory animal welfare ethics committee of the Jinan University.
Conflict-of-interest statement: The authors have no conflicts of interest to disclose.
ARRIVE guidelines statement: The authors have read the ARRIVE guidelines, and the manuscript was prepared and revised according to the ARRIVE guidelines.
Data sharing statement: The data are available from the corresponding author at niuboshi@fudahospital.com.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Li-Zhi Niu, MAMS, MD, PhD, Chief Physician, Department of Oncology, Guangzhou Fuda Cancer Hospital, No. 2 Tangde West Road, Tianhe District, Guangzhou 510665, Guangdong Province, China. niuboshi@fudahospital.com
Received: October 4, 2024
Revised: November 21, 2024
Accepted: January 8, 2025
Published online: March 15, 2025
Processing time: 133 Days and 6.8 Hours
Core Tip

Core Tip: This study highlighted the synergistic effect of combining irreversible electroporation with anti-programmed cell death protein 1 therapy in the treatment of subcutaneous pancreatic cancer. The combination significantly enhanced T lymphocyte infiltration, elevated key cytokine levels, and promoted CD8+ T cell-mediated immune responses, resulting in a marked reduction in tumor volume. These findings suggest a promising avenue for improving immunotherapy strategies in pancreatic cancer through enhanced local tumor ablation methods.