Letter to the Editor
Copyright ©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Oncol. Mar 15, 2025; 17(3): 101857
Published online Mar 15, 2025. doi: 10.4251/wjgo.v17.i3.101857
Exosome technology: A novel and effective drug delivery system in the field of cancer therapy
Jia-Xin Geng, Yao-Fan Lu, Jing-Nan Zhou, Biao Huang, Yuan Qin
Jia-Xin Geng, Yao-Fan Lu, Biao Huang, Yuan Qin, College of Life Sciences and Medicine, Zhejiang Sci-Tech University, Hangzhou 310018, Zhejiang Province, China
Jing-Nan Zhou, Zhejiang Cancer Hospital, Hangzhou 310018, Zhejiang Province, China
Author contributions: Qin Y designed this study; Geng JX, Lu YF, Zhou JN and Huang B performed the reference analyses; while Geng JX wrote the initial draft of the paper, with contributions from all authors.
Supported by Natural Science Foundation of Zhejiang Province, No. LQ23H050005; Zhejiang Medical and Health Science and Technology Project, No. 2023KY615; Scientific Research Project of Zhejiang Provincial Education Department, No. Y202250731 and No. Y202353130; the China Students’ Innovation and Entrepreneurship Training Program, No. 202310338044; China Postdoctoral Science Foundation, No. 2022M721720.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Yuan Qin, PhD, Associate Professor, College of Life Sciences and Medicine, Zhejiang Sci-Tech University, No. 928 Second Avenue, Qiantang District, Hangzhou 310018, Zhejiang Province, China. qinyuan@zstu.edu.cn
Received: September 28, 2024
Revised: November 23, 2024
Accepted: December 20, 2024
Published online: March 15, 2025
Processing time: 138 Days and 19.1 Hours
Core Tip

Core Tip: The biocompatibility, targeting specificity, and low immunogenicity of exosomes render them as optimal carriers for drug delivery, enabling precise administration of therapeutics to diseased tissues, thereby achieving targeted treatment of cancer cells. However, the clinical application of exosome drug delivery platforms in oncology still presents challenges, necessitating further optimization to ensure their stability and efficacy. This study focuses on elucidating the advantages of exosomes as a drug delivery platform, exploring the utilization of mesenchymal stem cell-derived exosomes in oncology therapy, and discussing their potential and future directions in cancer treatment.