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©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Oncol. Mar 15, 2025; 17(3): 100463
Published online Mar 15, 2025. doi: 10.4251/wjgo.v17.i3.100463
Published online Mar 15, 2025. doi: 10.4251/wjgo.v17.i3.100463
Characteristics and therapeutic strategies for familial gastrointestinal stromal tumors
Yuan Liu, Xiao-Feng Li, Department of Gastroenterology, The Fifth Affiliated Hospital of Sun Yat-sen University, Zhuhai 519000, Guangdong Province, China
Author contributions: Li XF and Liu Y jointly participated in the discussion and literature review; Li XF designed the overall concept and outlined the manuscript; Liu Y was involved in the writing of the manuscript.
Supported by National Natural Science Foundation of China, No. 82370569; Basic and Applied Basic Research Foundation of Guangdong Province, No. 2022A1515012647; and the Key Program for Science and Technology Projects of Social Development in Zhuhai, No. 2220004000249 (to Li XF).
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Xiao-Feng Li, PhD, Professor, Department of Gastroenterology, The Fifth Affiliated Hospital of Sun Yat-sen University, No. 52 Meihua East Road, Xiangzhou District, Zhuhai 519000, Guangdong Province, China. zdwylxf@163.com
Received: August 17, 2024
Revised: November 4, 2024
Accepted: December 16, 2024
Published online: March 15, 2025
Processing time: 181 Days and 8.1 Hours
Revised: November 4, 2024
Accepted: December 16, 2024
Published online: March 15, 2025
Processing time: 181 Days and 8.1 Hours
Core Tip
Core Tip: The management of familial gastrointestinal stromal tumors (GISTs) depends on the conduct of genetic surveillance, with early screening for first-degree relatives being essential. Current treatment strategies are essentially the same as those used for sporadic GISTs, primarily consisting of surgery and tyrosine kinase inhibitor targeted therapy. For familial GISTs, additional experience and evidence are required for treatment, prognosis, and monitoring; therefore, it is advisable to adopt more proactive therapeutic and follow-up strategies.