Innovative applications and research progress of hepatic arterial infusion chemotherapy in the treatment of advanced hepatocellular carcinoma

doi:10.4251/wjgo.v17.i2.99332

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Feb 15, 2025 (publication date) through Jan 20, 2025

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World Journal of Gastrointestinal Oncology

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1948-5204

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastrointest Oncol. Feb 15, 2025; 17(2): 99332
Published online Feb 15, 2025. doi: 10.4251/wjgo.v17.i2.99332

Innovative applications and research progress of hepatic arterial infusion chemotherapy in the treatment of advanced hepatocellular carcinoma

Ting-Fang Yang, Mo-Wei Kong

Ting-Fang Yang, Department of Oncology, Guiqian International General Hospital, Guiyang 550018, Guizhou Province, China

Mo-Wei Kong, Department of Cardiology, The Affiliated Hospital of Southwest Medical University, Luzhou 646000, Sichuan Province, China

Author contributions: Yang TF wrote the manuscript; Kong MW reviewed and revised the manuscript; and all authors read and approved the final manuscript.

Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.

Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/

Corresponding author: Mo-Wei Kong, Department of Cardiology, The Affiliated Hospital of Southwest Medical University, No. 1 Section 1, Xiang Lin Road, Longmatan District, Luzhou 646000, Sichuan Province, China. 1600181272@qq.com

Received: July 19, 2024
Revised: October 23, 2024
Accepted: November 27, 2024
Published online: February 15, 2025
Processing time: 182 Days and 14.4 Hours

Core Tip

Core Tip: Hepatic arterial infusion chemotherapy (HAIC) is an innovative regional chemotherapy technique for treating advanced hepatocellular carcinoma. It leverages the differential blood supply between liver tumors and normal liver tissue to deliver high concentrations of chemotherapy drugs directly to tumor tissues, enhancing efficacy while minimizing systemic side effects. Recent advancements in interventional radiology have made precise drug delivery possible, improving the safety and operability of HAIC. The combination of HAIC with targeted therapy and immunotherapy offers a more comprehensive and personalized treatment approach for hepatocellular carcinoma patients.