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©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Oncol. Feb 15, 2025; 17(2): 97298
Published online Feb 15, 2025. doi: 10.4251/wjgo.v17.i2.97298
Published online Feb 15, 2025. doi: 10.4251/wjgo.v17.i2.97298
Pancreatic primitive neuroectodermal tumors: Clinical features, treatment, and influencing factors
Yan-Fei He, Jie Wang, Shuang-Feng Lu, Health Management Center, The Sixth Medical Center, Chinese PLA General Hospital, Beijing 100048, China
Huan-Zhi Wang, College of Atmospheric Sciences, Lanzhou University, Lanzhou 730000, Gansu Province, China
Xiao-Dong Hu, Department of Endocrinology, The Sixth Medical Center, Chinese PLA General Hospital, Beijing 100048, China
Jun-Qiang Liu, Department of Thoracic Surgery, The Sixth Medical Center, Chinese PLA General Hospital, Beijing 100048, China
Hu-Ming Li, Department of Respiratory Medicine, The Sixth Medical Center, Chinese PLA General Hospital, Beijing 100048, China
Author contributions: He YF designed the study, reviewed the literature, and drafted the manuscript; Wang HZ contributed to the data analyses; Hu XD, Liu JQ, and Wang J contributed to the data collection; Wang HZ, Li HM, and Lu SF contributed to the study design; All authors read and approved the final version of the manuscript.
Conflict-of-interest statement: The authors have no conflicts of interest to declare.
PRISMA 2009 Checklist statement: The authors have read the PRISMA 2009 Checklist, and the manuscript was prepared and revised according to the PRISMA 2009 Checklist.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Yan-Fei He, MD, Associate Chief Physician, Doctor, Health Management Center, The Sixth Medical Center, Chinese PLA General Hospital, No. 6 Fu Cheng Road, Haidian District, Beijing 100048, China. heyanfeilc@163.com
Received: May 27, 2024
Revised: October 1, 2024
Accepted: November 1, 2024
Published online: February 15, 2025
Processing time: 235 Days and 16.4 Hours
Revised: October 1, 2024
Accepted: November 1, 2024
Published online: February 15, 2025
Processing time: 235 Days and 16.4 Hours
Core Tip
Core Tip: Pancreatic primitive neuroectodermal tumor (PNET) is a rare disease, which lacks sound treatment strategies and prognostic data. We identified 30 cases of pancreatic PNET from global databases and retrospectively analyzed their demographic data, clinical characteristics, and treatment factors. Univariate analysis showed that surgical margins, chemotherapy, local metastasis, lymph node metastasis, and distant metastasis were the prognostic factors affecting survival. Multivariate analysis revealed that only lymph node metastasis was a significant prognostic factor. The results of this study suggest that early diagnosis of pancreatic PNET is critical, and early wide resection and adjuvant radiotherapy may help to improve prognosis.