Basic Study
Copyright ©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Oncol. Feb 15, 2025; 17(2): 96230
Published online Feb 15, 2025. doi: 10.4251/wjgo.v17.i2.96230
LncRNA PCAT6 promotes progression and metastasis of colonic neuroendocrine carcinoma via MAPK pathway
Fei Wang, Hai-Feng Mu, Chun Wang, Yue Tang, Ming-Yuan Si, Jing Peng
Fei Wang, Hai-Feng Mu, Chun Wang, Yue Tang, Jing Peng, Department of General Surgery, Nanjing Tongren Hospital, Nanjing 211100, Jiangsu Province, China
Ming-Yuan Si, Department of Pathology, Nanjing Tongren Hospital, Nanjing 211100, Jiangsu Province, China
Co-first authors: Fei Wang and Hai-Feng Mu.
Author contributions: Wang F and Mu HF conceived and designed the experiments; Wang F, Mu HF, Wang C, Tang Y, Si MY and Peng J carried out the experiments; Wang F, Mu HF and Peng J analyzed the data, drafted the manuscript. All authors agreed to be accountable for all aspects of the work. All authors have read and approved the final manuscript.
Institutional review board statement: Our study was approved by the Ethics Committee of Nanjing Tongren Hospital (2022-03-016). All patients had signed an informed consent before the study.
Institutional animal care and use committee statement: All animal experiments were reviewed and approved by the Ethics Review Committee of Southeast University (20210701004) and were performed in strict accordance with the National Institutes of Health Guide for the Care and Use of Laboratory Animals.
Conflict-of-interest statement: The authors declare that they have no competing interests.
Data sharing statement: The datasets used or analyzed during the current study are available from the corresponding author on reasonable request.
ARRIVE guidelines statement: The authors have read the ARRIVE guidelines, and the manuscript was prepared and revised according to the ARRIVE guidelines.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Jing Peng, MM, Department of General Surgery, Nanjing Tongren Hospital, No. 2007 Jiyin Avenue, Jiangning District, Nanjing 211100, Jiangsu Province, China. pengjingwxn@163.com
Received: April 30, 2024
Revised: September 18, 2024
Accepted: December 2, 2024
Published online: February 15, 2025
Processing time: 263 Days and 2 Hours
Core Tip

Core Tip: Prostate cancer associated transcript 6 (PCAT6) is highly expressed in neuroendocrine carcinomas (NECs) tissues and cells PCAT6 promotes the proliferation, migration and invasion of NEC cells PCAT6 facilitates tumor growth and lung metastasis in vivo PCAT6 enhances the epithelial-mesenchymal transition (EMT) in NECPCAT6 promotes the activation of MAPK to enhance the EMT in NEC.