Basic Study
Copyright ©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Oncol. Jan 15, 2025; 17(1): 99376
Published online Jan 15, 2025. doi: 10.4251/wjgo.v17.i1.99376
BIBR1532 inhibits proliferation and metastasis of esophageal squamous cancer cells by inducing telomere dysregulation
Qin Wang, Qing-Rong Li, Lei Xu, Zi-Chun Yuan, Xiao Liu, Mao-Ju Tang, Man Luo, Xiao-Wu Zhong, Qiang Ma, Xiao-Lan Guo
Qin Wang, Qing-Rong Li, Zi-Chun Yuan, Man Luo, Xiao-Wu Zhong, Qiang Ma, Xiao-Lan Guo, Department of Clinical Laboratory, Affiliated Hospital of North Sichuan Medical College, Nanchong 637000, Sichuan Province, China
Qin Wang, Qing-Rong Li, Lei Xu, Zi-Chun Yuan, Xiao Liu, Mao-Ju Tang, Man Luo, Xiao-Wu Zhong, Qiang Ma, Xiao-Lan Guo, School of Laboratory Medicine & Translational Medicine Research Center, North Sichuan Medical College, Nanchong 637000, Sichuan Province, China
Co-first authors: Qin Wang and Qing-Rong Li.
Co-corresponding authors: Qiang Ma and Xiao-Lan Guo.
Author contributions: Guo XL and Ma Q contributed to conceptualization; Yuan ZC, Liu X, and Zhong XW contributed to investigation; Wang Q, Li QR, Xu L, Yuan ZC, Liu X, Tang MJ, Luo M, and Zhong XW contributed to methodology; Wang Q, Li QR, and Ma Q contributed to writing-original draft; Guo XL contributed to writing-review and editing; and all authors have read and approved the manuscript.
Supported by the Scientific Research Development Plan Project or the Scientific Research Foundation for Advanced Talents, Affiliated Hospital of North Sichuan Medical College, No. 2023MPZK017, No. 2023ZD001, No. 2023-2ZD002, and No. 2023GC009; Science and Technology Support Program of Nanchong, No. 22SXQT0001; Youth Medical Innovation Research Project, or Medical Research Project of Sichuan Province, No. Q23047 and No. S23020; and Development of a Scientific Research Plan for the Doctoral Scientific Research Foundation of the North Sichuan Medical College, No. CBY22-ZDA03.
Institutional animal care and use committee statement: The studies involving animals were reviewed and approved by the Ethics Committee of the North Sichuan Medical College (approval No. 2023033).
Conflict-of-interest statement: The authors declared that there are no conflicts of interest.
Data sharing statement: The data supporting the findings of this study are available from the corresponding author upon reasonable request.
ARRIVE guidelines statement: The authors have read the ARRIVE guidelines, and the manuscript was prepared and revised according to the ARRIVE guidelines.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Xiao-Lan Guo, MD, PhD, Professor, Department of Clinical Laboratory, Affiliated Hospital of North Sichuan Medical College, No. 1 South Maoyuan Road, Shunqing District, Nanchong 637000, Sichuan Province, China. alan5200@hotmail.com
Received: July 21, 2024
Revised: October 5, 2024
Accepted: November 1, 2024
Published online: January 15, 2025
Processing time: 144 Days and 0.7 Hours
Core Tip

Core Tip: BIBR1532 inhibited proliferation and metastasis of esophageal squamous cell carcinoma (ESCC) cells in a dose-dependent manner, which also effectively blocked the growth of ESCC in tumor-bearing nude mouse model. Mechanistically, BIBR1532 downregulated the expression of telomere-binding proteins, upregulated the expression of phosphorylated histone H2AX, ataxia telangiectasia and Rad3-related protein/check point kinase 1 (CHK-1) and ataxia-telangiectasia mutated gene/CHK2 pathways. The in vitro and in vivo studies showed that BIBR1532 is a potential chemotherapeutic drug for ESCC.