Wu XR, He XH, Xie YF. Characteristics of gut microbiota dysbiosis in patients with colorectal polyps. World J Gastrointest Oncol 2025; 17(1): 98872 [DOI: 10.4251/wjgo.v17.i1.98872]
Corresponding Author of This Article
Yong-Fang Xie, MD, Doctor, School of Life Health Information Science and Engineering, Chongqing Post and Communications University, No. 2 Chongwen Road, Nanan District, Chongqing 400065, China. xyf1688@126.com
Research Domain of This Article
Biochemistry & Molecular Biology
Article-Type of This Article
Editorial
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Gastrointest Oncol. Jan 15, 2025; 17(1): 98872 Published online Jan 15, 2025. doi: 10.4251/wjgo.v17.i1.98872
Characteristics of gut microbiota dysbiosis in patients with colorectal polyps
Xian-Rong Wu, Xiao-Hong He, Yong-Fang Xie
Xian-Rong Wu, Xiao-Hong He, Yong-Fang Xie, School of Life Health Information Science and Engineering, Chongqing Post and Communications University, Chongqing 400065, China
Co-first authors: Xian-Rong Wu and Xiao-Hong He.
Author contributions: Wu XR, He XH compiled and drafted the literature review, and proposed the overall framework of the article; contributed to assisted in the literature review, provided critical academic insights and analysis, and made significant revisions to the article; Xie YF oversaw the overall direction of the article, reviewed and revised various sections, ensuring the accuracy and completeness of the academic content.
Conflict-of-interest statement: The authors declare no potential conflict of interests.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Yong-Fang Xie, MD, Doctor, School of Life Health Information Science and Engineering, Chongqing Post and Communications University, No. 2 Chongwen Road, Nanan District, Chongqing 400065, China. xyf1688@126.com
Received: July 9, 2024 Revised: September 5, 2024 Accepted: September 19, 2024 Published online: January 15, 2025 Processing time: 156 Days and 6.5 Hours
Core Tip
Core Tip: This review addresses gut microbiota dysbiosis in patients with recurrent colorectal polyps, noting increased levels of Klebsiella, Parvimonas, and Clostridium and decreased levels of Bifidobacterium and Lactobacillus. This dysbiosis may promote polyp formation and recurrence by creating an inflammatory gut environment. A reduction in probiotics weakens intestinal barrier function, while an increase in pathogens further degrades the gut through their metabolic products and toxins. These changes are also observed in colorectal cancer, inflammatory bowel disease, autism spectrum disorder, and metabolic syndrome. Regulating the gut microbiota, particularly by increasing the use of probiotics, may restore gut health and prevent polyp recurrence. Future research should explore specific mechanisms and evaluate long-term effects.
