Case Control Study
Copyright ©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Oncol. Jan 15, 2025; 17(1): 96702
Published online Jan 15, 2025. doi: 10.4251/wjgo.v17.i1.96702
Activin A receptor type 1C single nucleotide polymorphisms associated with esophageal squamous cell carcinoma risk in Chinese population
Si-Yun Lin, Hou Huang, Jin-Jie Yu, Feng Su, Tian Jiang, Shao-Yuan Zhang, Lu Lv, Tao Long, Hui-Wen Pan, Jun-Qing Qi, Qiang Zhou, Wei-Feng Tang, Guo-Wen Ding, Li-Ming Wang, Li-Jie Tan, Jun Yin
Si-Yun Lin, Jin-Jie Yu, Feng Su, Tian Jiang, Shao-Yuan Zhang, Li-Jie Tan, Jun Yin, Department of Thoracic Surgery, Zhongshan Hospital Affiliated to Fudan University, Shanghai 200032, China
Si-Yun Lin, Hou Huang, Shanghai Key Laboratory of Clinical Geriatric Medicine, Huadong Hospital Affiliated to Fudan University, Shanghai 200040, China
Lu Lv, Tao Long, Hui-Wen Pan, Jun-Qing Qi, Guo-Wen Ding, Department of Cardiothoracic Surgery, The Affiliated People's Hospital of Jiangsu University, Zhenjiang 212002, Jiangsu Province, China
Qiang Zhou, Department of Thoracic Surgery, Sichuan Cancer Hospital & Institute, Chengdu 610042, Sichuan Province, China
Wei-Feng Tang, Department of Cardiothoracic Surgery, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing 210000, Jiangsu Province, China
Li-Ming Wang, Department of Respiratory and Critical Care Medicine, Shanghai Xuhui Central Hospital, Shanghai 200032, China
Co-first authors: Si-Yun Lin and Hou Huang.
Co-corresponding authors: Li-Jie Tan and Jun Yin.
Author contributions: Yin J and Tan LJ conceptualized and designed the research; Yin J, Lv L, Long T, Pan HW, Qi JQ, Zhou Q and Tang WF screened patients and acquired clinical data; Yin J, Lv L and Long T collected blood specimen and performed laboratory analysis; Huang H and Lin SY performed Data analysis and wrote the first draft of the manuscript; Lin SY was responsible for data re-analysis and re-interpretation, figure plotting, comprehensive literature search, preparation and submission of the current version of the manuscript; Yu JJ, Su F and Zhang SY provided suggestions on the methodology and writing guidance; Jiang T and Wang LM helped revise the manuscript; Ding GW, Tan LJ and Yin J were responsible for study administration; All the authors have read and approved the final manuscript. Both Lin SY and Huang H have made crucial and indispensable contributions towards the completion of the project and thus qualified as the co-first authors of the paper. Both Tan LJ and Yin J have played important and indispensable roles in the experimental design, data interpretation and manuscript preparation as the co-corresponding authors. Yin J and Wang LM applied for and obtained the funds for this research project.
Supported by The National Natural Science Foundation of China, No. 82350127 and No. 82241013; the Shanghai Natural Science Foundation, No. 20ZR1411600; the Shanghai Shenkang Hospital Development Center, No. SHDC2020CR4039; the Bethune Ethicon Excellent Surgery Foundation, No. CESS2021TC04; and Xuhui District Medical Research Project of Shanghai, No. SHXH201805.
Institutional review board statement: The study was reviewed and approved by the Ethics Committee of Jiangsu University (Zhenjiang, China) and the Review Board of the institution (Approval No. K20160036-W).
Informed consent statement: All recruited participants were provided with informed consent.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Data sharing statement: The dataset generated and analyzed during the current study are available in 1000Genomes project [1000G: PRJEB6930] from the NCBI SNP database. The genotype data of the selected SNPs used to support the findings of this study are available from the corresponding author on reasonable request at jun_yin@fudan.edu.cn.
STROBE statement: The authors have read the STROBE Statement—checklist of items, and the manuscript was prepared and revised according to the STROBE Statement—checklist of items.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Jun Yin, MD, PhD, Professor, Department of Thoracic Surgery, Zhongshan Hospital Affiliated to Fudan University, No. 180 Fenglin Road, Xuhui District, Shanghai 200032, China. jun_yin@fudan.edu.cn
Received: May 13, 2024
Revised: September 1, 2024
Accepted: October 14, 2024
Published online: January 15, 2025
Processing time: 212 Days and 20.3 Hours
Core Tip

Core Tip: In this study, a case-control approach was used to investigate the association between specific single nucleotide polymorphisms (SNPs) of the ACVR1C gene and the risk of esophageal squamous cell carcinoma (ESCC) in a Chinese Han population. The study included 2186 participants, comprising 1043 ESCC patients and 1143 healthy controls. Notably, the rs4556933 G>A SNP was significantly associated with ESCC risk across several genetic models. Stratified analysis indicated an increased risk in older males and smokers. These findings suggest that ACVR1C SNPs play a critical role in ESCC susceptibility, meriting further investigation into their involvement in cancer development.