Case Report
Copyright ©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Oncol. Jan 15, 2025; 17(1): 100757
Published online Jan 15, 2025. doi: 10.4251/wjgo.v17.i1.100757
Targeted gene sequencing and bioinformatics analysis of patients with gallbladder neuroendocrine carcinoma: A case report
Yun-Chuan Yang, Zhi-Tao Chen, Da-Long Wan, Hui Tang, Mu-Lin Liu
Yun-Chuan Yang, Mu-Lin Liu, Department of Medical College, Jinan University, Guangzhou 510000, Guangdong Province, China
Yun-Chuan Yang, Mu-Lin Liu, Department of General Surgery, The First Affiliated Hospital of Bengbu Medical University, Bengbu 233000, Anhui Province, China
Zhi-Tao Chen, Department of Hepatobiliary Surgery, Shulan (Hangzhou) Hospital Affiliated to Zhejiang Shuren University Shulan International Medical College, Hangzhou 310022, Zhejiang Province, China
Da-Long Wan, Department of Hepatobiliary and Pancreatic Surgery, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou 310003, Zhejiang Province, China
Hui Tang, Department of Pathology, The First Affiliated Hospital of Medical School of Zhejiang University, Hangzhou 310000, Zhejiang Province, China
Author contributions: Yang YC, Chen ZT, and Wan DL made substantial contributions to the conception and design of the study and critically revised the manuscript; Yang YC and Chen ZT were responsible for data collection, analysis, and manuscript writing; Tang H performed pathological evaluations; Wan DL and Liu ML made critical revisions; all authors assume full responsibility for the integrity and accuracy of the work, ensuring that all relevant queries were appropriately addressed; the final version of the manuscript has been reviewed and approved by all authors.
Supported by School-Level Key Projects at Bengbu Medical College, No. 2021byzd109.
Informed consent statement: Informed written consent was obtained from the patient for the publication of this report and the accompanying images.
Conflict-of-interest statement: All the authors state that there are no conflicts of interest to declare.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Mu-Lin Liu, PhD, Chief Doctor, Department of General Surgery, The First Affiliated Hospital of Bengbu Medical University, No. 287 Changhuai Road, Longzihu District, Bengbu 233000, Anhui Province, China. liumulin66@aliyun.com
Received: August 26, 2024
Revised: September 26, 2024
Accepted: October 30, 2024
Published online: January 15, 2025
Processing time: 108 Days and 21.9 Hours
Core Tip

Core Tip: Gallbladder neuroendocrine carcinoma (NEC) is a rare and aggressive malignancy with unclear genetic alterations and mechanisms. Our case study of a 73-year-old female with gallbladder NEC revealed 12 mutated genes (APC, ARID2, IFNA6, KEAP1, RB1, SMAD4, TP53, BTK, GATA1, GNAS, JAK2, PRDM3) and a high tumor mutation burden. Bioinformatic analysis identified significant protein-protein interactions and tumor-related functions/pathways, highlighting key regulatory factors. Gallbladder NEC exhibits distinct molecular profiles compared to other gallbladder carcinomas, emphasizing the need for tailored therapeutic strategies and further research to unravel its underlying biology.