Basic Study
Copyright ©The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Oncol. Sep 15, 2024; 16(9): 3994-4005
Published online Sep 15, 2024. doi: 10.4251/wjgo.v16.i9.3994
Senegenin suppresses hepatocellular carcinoma by regulating O-GlcNAcylation
Xiang Zhang, Li-Qiong Wang, Zhi-Yong Liu
Xiang Zhang, Zhi-Yong Liu, Department of Traditional Chinese Medicine, Qingpu Branch of Zhongshan Hospital Affiliated to Fudan University, Shanghai 201700, China
Li-Qiong Wang, Department of Hepatology, Longhua Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai 200032, China
Co-first authors: Xiang Zhang and Li-Qiong Wang.
Author contributions: Zhang X and Wang LQ drafted the manuscript, performed the experiments, and prepared the figures; Liu ZY checked and guided for this manuscript; Zhang X and Wang LQ contributed equally to this work.
Institutional animal care and use committee statement: Upon review, it has been determined that this study does not involve interventions or interactions with human or animal subjects, nor does it involve access to identifiable private information. The research scope is confined to the use of established cell lines, which are fully compliant with ethical standards for research without direct involvement of human or animal subjects.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Data sharing statement: The data used to support the findings of this study are available from the corresponding author upon request at lzhy780404@163.com.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Zhi-Yong Liu, MD, Associate Chief Physician, Department of Traditional Chinese Medicine, Qingpu Branch of Zhongshan Hospital Affiliated to Fudan University, No. 1158 Park Road East, Qingpu District, Shanghai 201700, China. lzhy780404@163.com
Received: May 21, 2024
Revised: July 4, 2024
Accepted: August 1, 2024
Published online: September 15, 2024
Processing time: 110 Days and 13.5 Hours
Core Tip

Core Tip: This study investigated the effects of senegenin and O-GlcNAcylation on the growth and metastasis of hepatocellular carcinoma (HCC) cells. The findings indicated that O-GlcNAcylation levels are elevated in HCC tissues and cells, and senegenin can reduce these levels by targeting proteins involved in nuclear factor-kappa B and c-Jun N-terminal kinase signaling pathways. This modulation decreases the levels of O-linked N-acetylglucosamine transferase and inhibits the proliferation and metastasis of HCC cells, providing new therapeutic targets for liver cancer.