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©The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Oncol. Aug 15, 2024; 16(8): 3600-3623
Published online Aug 15, 2024. doi: 10.4251/wjgo.v16.i8.3600
Published online Aug 15, 2024. doi: 10.4251/wjgo.v16.i8.3600
Dysbiosis promotes recurrence of adenomatous polyps in the distal colorectum
Li-Li Yin, Ping-Qian Qi, Yun-Fei Hu, Xiao-Jun Fu, Meng-Meng Wang, Yan-Juan Deng, Su-Yi Xiong, Qi-Wen Yu, Jin-Ping Hu, Lv Zhou, Zhi-Bin Zhou, Huan Deng, The Affiliated Rehabilitation Hospital, Jiangxi Medical College, Nanchang University, Nanchang 330006, Jiangxi Province, China
Li-Li Yin, Ping-Qian Qi, Yun-Fei Hu, Xiao-Jun Fu, Meng-Meng Wang, Yan-Juan Deng, Su-Yi Xiong, Qi-Wen Yu, Jin-Ping Hu, Lv Zhou, Zhi-Bin Zhou, Huan Deng, The Fourth Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang 330006, Jiangxi Province, China
Rui-Shan He, The Second College of Clinical Medicine, Jiangxi Medical College, Nanchang University, Nanchang 330006, Jiangxi Province, China
Meng-Meng Wang, Yan-Juan Deng, Su-Yi Xiong, Qi-Wen Yu, Jin-Ping Hu, Lv Zhou, Zhi-Bin Zhou, Huan Deng, Tumor Immunology Institute, Nanchang University, Nanchang 330006, Jiangxi Province, China
Ying Xiong, Department of General Medicine, The Second College of Clinical Medicine, Jiangxi Medical College, Nanchang University, Nanchang 330031, Jiangxi Province, China
Huan Deng, The Ministry of Education Basic Research and Innovation Center for the Targeted Therapeutics of Solid Tumors, Jiangxi Medical College, Nanchang University, Nanchang 330031, Jiangxi Province, China
Co-corresponding authors: Ying Xiong and Huan Deng.
Author contributions: Yin LL, Fu XJ, Xiong Y, and Deng H designed the research study; Yin LL, Qi PQ, Hu YF, Fu XJ, He RS, and Deng H wrote the manuscript; Yin LL, Qi PQ, Hu YF, Fu XJ, He RS, Wang MM, Deng YJ, Xiong SY, Yu QW, Hu JP, Zhou L, and Zhou ZB collected the clinical data and pathological photographs; Yin LL analyzed the data and drew the figures; and all authors have read and approved the final manuscript. Xiong Y and Deng H contributed equally to this study as co-corresponding authors.
Supported by National Science Foundation of China , No. 82160546 ; the Science Foundation of Jiangxi Province , No. 20202BBG73027 ; the Foundation of Jiangxi Province for Distinguished Scholars , No. jxsq2023201020 ; and the Science and Technology Project of Jiangxi Administration of Traditional Chinese Medicine , No. 2022B789 .
Institutional review board statement: This study was conducted in accordance with the Declaration of Helsinki and approved by the Ethics Committee of the Fourth Affiliated Hospital of Nanchang University (No. SFYYXLL-PJ-2021-KY018). Each patient provided written informed consent for the collection of samples and subsequent analysis.
Institutional animal care and use committee statement: All mouse studies were approved by the Fourth Affiliated Hospital of Nanchang University Institutional Animal Care and Use Committee (No. 2017-024).
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Data sharing statement: The original contributions presented in the study are included in the article (Supplementary material), further inquiries can be directed to the corresponding author.
ARRIVE guidelines statement: The authors have read the ARRIVE guidelines, and the manuscript was prepared and revised according to the ARRIVE guidelines.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Huan Deng, MD, PhD, Professor, The Affiliated Rehabilitation Hospital, Jiangxi Medical College, Nanchang University, No. 133 South Guangchang Road, Nanchang 330006, Jiangxi Province, China. beandeng@ncu.edu.cn
Received: February 14, 2024
Revised: May 19, 2024
Accepted: June 14, 2024
Published online: August 15, 2024
Processing time: 174 Days and 21.7 Hours
Revised: May 19, 2024
Accepted: June 14, 2024
Published online: August 15, 2024
Processing time: 174 Days and 21.7 Hours
Core Tip
Core Tip: This study investigates the links between intestinal dysbiosis and recurrent colorectal polyps using 16S rDNA sequencing. The findings reveal reduced probiotics and increased pathogenic bacteria in the mucosa surrounding or 10 cm distal to the polyps. Significant differences in bacterial diversity were found among the normal mucosa, non-adenomous polyps, and adenomous polyps. Increased Gram-negative bacteria, such as Klebsiella, Plesiomonas, and Cronobacter, suggest that antibiotic resistance may contribute to the establishment of a harmful environment. Age and gender also influence bacterial changes, indicating the involvement of sex hormones. Targeting specific pathogenic bacteria may facilitate the prevention of recurrent polyps.