Retrospective Cohort Study
Copyright ©The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Oncol. Aug 15, 2024; 16(8): 3457-3470
Published online Aug 15, 2024. doi: 10.4251/wjgo.v16.i8.3457
Effect of perioperative chemotherapy on resection of isolated pulmonary metastases from colorectal cancer: A single center experience
Zhao Gao, Xuan Jin, Ying-Chao Wu, Shi-Jie Zhang, Shi-Kai Wu, Xin Wang
Zhao Gao, Xuan Jin, Shi-Kai Wu, Department of Medical Oncology, Peking University First Hospital, Beijing 10000, China
Ying-Chao Wu, Xin Wang, Department of General Surgery, Peking University First Hospital, Beijing 10000, China
Shi-Jie Zhang, Department of Thoracic Surgery, Peking University First Hospital, Beijing 10000, China
Co-first authors: Zhao Gao and Xuan Jin.
Co-corresponding authors: Shi-Kai Wu and Xin Wang.
Author contributions: Gao Z and Jin X wrote the manuscript as co-first authors; Wu SK and Wang X conceived of the review and edited the manuscript as co-corresponding authors; Gao Z collected and analyzed the data; Jin X, Wu YC, and Zhang SJ analyzed the data and drafted the article; Gao Z and Jin X contributed equally to this work; and all authors read and approved the final manuscript.
Supported by the 2020 National and Provincial Clinical Key Specialty Capacity Building Projects, No. 2020641.
Institutional review board statement: Our study complies with all ethical regulations of the Peking University First Hospital Ethics Committee (Approval No. 2024-321-001).
Informed consent statement: All study participants, or their legal guardian, provided informed written consent prior to study enrollment.
Conflict-of-interest statement: The authors have no relevant financial or non-financial interests to disclose.
Data sharing statement: The datasets generated during and/or analyzed during the current study are available from the corresponding author on reasonable request.
STROBE statement: The authors have read the STROBE Statement—checklist of items, and the manuscript was prepared and revised according to the STROBE Statement—checklist of items.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Shi-Kai Wu, PhD, Chief Doctor, Department of Medical Oncology, Peking University First Hospital, No. 8 Xishiku Street, Beijing 10000, China. skywu4923@sina.cn
Received: May 11, 2024
Revised: June 21, 2024
Accepted: June 27, 2024
Published online: August 15, 2024
Processing time: 88 Days and 23.7 Hours
Core Tip

Core Tip: Several studies have evaluated surgical resection of isolated pulmonary metastasis as a standard treatment option for colorectal cancer (CRC) patients with resectable pulmonary metastases (PM). However, the role of peri-operative chemotherapy after complete resection of isolated PM from CRC patients is still controversial. We sought to determine whether peri-operative chemotherapy affects survival after radical resection of isolated PM from CRC. As a single center, our study still has certain value. At the same time, due to the long survival period of patients, they will receive a lot of subsequent treatments and there are many factors that interfere with the prognosis. We believe that cancer-specific survival can better reflect the focus of research on these patients, but many studies do not give this. Due to the lack of randomized prospective trials and high-level evidence, our study may support valuable data support for individual participant data meta-analysis and help further research on this type of disease.