Review
Copyright ©The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Oncol. Aug 15, 2024; 16(8): 3397-3409
Published online Aug 15, 2024. doi: 10.4251/wjgo.v16.i8.3397
Research progress on the development of hepatocyte growth factor/c-Met signaling pathway in gastric cancer: A review
Wu-Jie Wei, Ya-Li Hong, Yi Deng, Guan-Liang Wang, Jiang-Tao Qiu, Fang Pan
Wu-Jie Wei, Guan-Liang Wang, Fang Pan, Department of Oncology, People's Hospital of Chongqing Hechuan, Chongqing 401520, China
Ya-Li Hong, Department of Cardiovascular, People's Hospital of Chongqing Hechuan, Chongqing 401520, China
Yi Deng, Intensive Care Unit, People's Hospital of Chongqing Hechuan, Chongqing 401520, China
Jiang-Tao Qiu, Department of Gastrointestinal Surgery, Beijing Tsinghua Changgung Hospital, Beijing 100084, China
Author contributions: Wei WJ wrote the manuscript; Hong YL, Deng Y, Wang GL, and Qiu JT collected the data; Pan F reviewed this review; All authors reviewed, edited, and approved the final manuscript and revised it critically for important intellectual content, gave final approval of the version to be published, and agreed to be accountable for all aspects of the work.
Conflict-of-interest statement: The authors have no conflicts of interest to declare.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/licenses/by-nc/4.0/
Corresponding author: Fang Pan, MD, Doctor, Department of Oncology, People's Hospital of Chongqing Hechuan, No. 1366 Hill'an Avenue, Nanjin Street Office, Hechuan District, Chongqing 401520, China. panfang124@163.com
Received: January 10, 2024
Revised: May 31, 2024
Accepted: June 21, 2024
Published online: August 15, 2024
Processing time: 210 Days and 14.7 Hours
Core Tip

Core Tip: Hepatocyte growth factor (HGF) and its receptor, c-Met, play important roles in the occurrence, development, and treatment of gastric cancer (GC). This review explored the function of the HGF/c-Met signaling pathway in GC and its potential targeted therapeutic mechanisms. As one of the most common malignant tumors worldwide, GC has a complex pathogenesis and limited therapeutic options. Therefore, a thorough understanding of the molecular mechanism of GC is important for the development of new therapeutic methods. The HGF/c-Met signaling pathway plays an important role in the proliferation, migration, and invasion of GC cells and has become a novel therapeutic target.