Case Report
Copyright ©The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Oncol. Jul 15, 2024; 16(7): 3357-3363
Published online Jul 15, 2024. doi: 10.4251/wjgo.v16.i7.3357
BRAF K601E-mutated metastatic colorectal cancer in response to combination therapy with encorafenib, binimetinib, and cetuximab: A case report
Makiko Sasaki, Takaya Shimura, Hirotada Nishie, Keita Kuroyanagi, Takuya Kanno, Shigeki Fukusada, Naomi Sugimura, Yusuke Mizuno, Takayuki Nukui, Konomu Uno, Yuki Kojima, Ruriko Nishigaki, Mamoru Tanaka, Keiji Ozeki, Eiji Kubota, Hiromi Kataoka
Makiko Sasaki, Takaya Shimura, Hirotada Nishie, Keita Kuroyanagi, Takuya Kanno, Shigeki Fukusada, Naomi Sugimura, Yusuke Mizuno, Takayuki Nukui, Konomu Uno, Yuki Kojima, Ruriko Nishigaki, Mamoru Tanaka, Keiji Ozeki, Eiji Kubota, Hiromi Kataoka, Department of Gastroenterology and Metabolism, Nagoya City University Graduate School of Medical Science, Nagoya 467-8601, Japan
Author contributions: Sasaki M contributed to data curation, software, investigation, and writing the original draft; Shimura T contributed to conceptualization, data curation, investigation, and reviewed draft; Nishie H contributed to data curation and investigation; Kuroyanagi K, Kanno T, Fukusada S, Sugimura N, Mizuno Y, Nukui T, Uno K, Kojima Y, Nishigaki R, Tanaka M, Ozeki K, and Kubota E contributed to resources; Kataoka H contributed to supervision; All authors have read and approved the final manuscript.
Informed consent statement: Informed consent has been obtained from the patients’ guardians/next of kin to participate and to publish this paper.
Conflict-of-interest statement: The authors have no conflicts of interest to declare.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Takaya Shimura, MD, PhD, Associate Professor, Department of Gastroenterology and Metabolism, Nagoya City University Graduate School of Medical Science, 1 Kawasumi, Mizuho, Nagoya 467-8601, Japan. tshimura@med.nagoya-cu.ac.jp
Received: April 20, 2024
Revised: May 21, 2024
Accepted: June 3, 2024
Published online: July 15, 2024
Processing time: 82 Days and 23.2 Hours
Core Tip

Core Tip: With the development and standardization of next-generation sequencing, it is anticipated that there will be increased discovery of previously unidentified genetic mutations. BRAF non-V600 mutations including the K601E mutation are rare, and the clinical behavior is not understood. In this case, a comprehensive genomic profiling panel revealed a BRAF K601E mutation, which was not covered in the initial companion diagnostics. A combination of encorafenib, binimetinib, and cetuximab had great effects. It is important to consider the possibility of discovering rare mutations, which could expand treatment options.