Scientometrics
Copyright ©The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Oncol. Jul 15, 2024; 16(7): 3321-3330
Published online Jul 15, 2024. doi: 10.4251/wjgo.v16.i7.3321
Research trends and hotspots in the immune microenvironment related to hepatocellular carcinoma: A bibliometric and visualization study
Da-Ya Zhang, Fei-Hu Bai
Da-Ya Zhang, Department of Graduate School, Hainan Medical University, Haikou 571199, Hainan Province, China
Fei-Hu Bai, Department of Gastroenterology, The Second Affiliated Hospital of Hainan Medical University, Haikou 570216, Hainan Province, China
Fei-Hu Bai, Department of Gastroenterology, The Gastroenterology Clinical Medical Center of Hainan Province, Haikou 570216, Hainan Province, China
Author contributions: Zhang DY and Bai FH designed the research study, performed the research, contributed new reagents and analytic tools, analyzed the data and wrote the manuscript; all authors have read and approve the final manuscript.
Supported by The Specific Research Fund of The Innovation Platform for Academicians of Hainan Province, No. YSPTZX202313; The Hainan Province Clinical Medical Center, No. 2021818; The Hainan Provincial Health Industry Research Project, No. 22A200078; The Hainan Provincial Postgraduate Innovation Research Project, No. Qhyb2022-133; and The National Clinical Key Specialty Capacity Building Project, No. 202330.
Conflict-of-interest statement: All authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
PRISMA 2009 Checklist statement: The authors have read the PRISMA 2009 Checklist statement, and the manuscript was prepared and revised according to the PRISMA 2009 Checklist statement.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Fei-Hu Bai, PhD, Chief Doctor, Professor, Department of Gastroenterology, The Second Affiliated Hospital of Hainan Medical University, No. 368 Yehai Avenue, Longhua District, Haikou 570216, Hainan Province, China. baifeihu_hy@163.com
Received: January 19, 2024
Revised: April 16, 2024
Accepted: April 28, 2024
Published online: July 15, 2024
Processing time: 175 Days and 13 Hours
Core Tip

Core Tip: The current major research thrust in the field is to explore immune microenvironment (IME)-based immunotherapy related to hepatocellular carcinoma. Our researchers have taken an in-depth look at tumor IME and concluded that immune checkpoint-based immunotherapy, precision immunotherapy and immune cellular modalities are the frontiers and priorities for the coming years, which may provide valuable opportunities for further research.