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©The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Oncol. Jul 15, 2024; 16(7): 3284-3298
Published online Jul 15, 2024. doi: 10.4251/wjgo.v16.i7.3284
Published online Jul 15, 2024. doi: 10.4251/wjgo.v16.i7.3284
Canopy FGF signaling regulator 3 affects prognosis, immune infiltration, and PI3K/AKT pathway in colon adenocarcinoma
Xu-Can Gao, Biao-Huan Zhou, Zhou-Xin Ji, Qiang Li, Hui-Ning Liu, Department of Anorectal Surgery, Shenzhen People’s Hospital (The Second Clinical Medical College, Jinan University, The First Affiliated Hospital, Southern University of Science and Technology), Shenzhen 518020, Guangdong Province, China
Author contributions: Gao XC, Zhou BH, Ji ZX, Li Q, and Liu HN designed the research study; Gao XC, Zhou BH, and Ji ZX performed the research; Li Q and Liu HN analyzed the data; Gao XC and Zhou BH wrote the manuscript; all authors have read and approved the final manuscript.
Institutional review board statement: The clinical sample collection process was performed after the approval of the local Ethics Committee. The study was reviewed and approved by the Shenzhen People’s Hospital Institutional Review Board (No. LL-KY-2021816).
Conflict-of-interest statement: The authors have no relevant financial or non-financial interests to disclose.
Data sharing statement: No additional data are available.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Xu-Can Gao, MD, Doctor, Department of Anorectal Surgery, Shenzhen People’s Hospital (The Second Clinical Medical College, Jinan University, The First Affiliated Hospital, Southern University of Science and Technology), No. 1017 Dongmen North Road, Cuizhu Street, Luohu District, Shenzhen 518020, Guangdong Province, China.logia@szhospital.com
Received: March 23, 2024
Revised: May 14, 2024
Accepted: June 4, 2024
Published online: July 15, 2024
Processing time: 111 Days and 8.6 Hours
Revised: May 14, 2024
Accepted: June 4, 2024
Published online: July 15, 2024
Processing time: 111 Days and 8.6 Hours
Core Tip
Core Tip: First, this is the first study reporting that canopy FGF signaling regulator 3 (CNPY3) was up-regulated in colon adenocarcinoma and might regulate tumor development and progression. Second, CNPY3 expression was validated in clinical samples and tumor cell lines. Third, functional experiments indicated that cell proliferation, invasion, and migration were inhibited and cell apoptosis was promoted after CNPY3 knockdown.