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©The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Oncol. Jul 15, 2024; 16(7): 3256-3269
Published online Jul 15, 2024. doi: 10.4251/wjgo.v16.i7.3256
Published online Jul 15, 2024. doi: 10.4251/wjgo.v16.i7.3256
Immune effect and prognosis of transcatheter arterial chemoembolization and tyrosine kinase inhibitors therapy in patients with hepatocellular carcinoma
Yuan Guo, Wei-Li Xia, Xiong Yang, Wen-Bo Zhu, Fang-Ting Li, Hong-Tao Hu, Hai-Liang Li, Department of Minimal Invasive Intervention, The Affiliated Cancer Hospital of Zhengzhou University, Henan Cancer Hospital, Zhengzhou 450003, Henan Province, China
Ru-Chun Li, Department of Radiology, The Affiliated Cancer Hospital of Zhengzhou University, Henan Cancer Hospital, Zhengzhou 450003, Henan Province, China
Co-first authors: Yuan Guo and Ru-Chun Li.
Co-corresponding authors: Hong-Tao Hu and Hai-Liang Li.
Author contributions: Guo Y and Li HL created the research design; Guo Y and Li RC wrote and edited the manuscript; Xia WL and Yang X collected the data; Zhu WB and Li FT performed the data analysis; Li HL and Hu HT conceptualized and supervised the study; and all the authors have read and approved the final version of the manuscript. Considering the author’s contribution to this study, Guo Y and Li RC are the co-first author, Hu HT and Li HL are the co-corresponding author.
Supported by Henan Province Natural Science Foundation , No. 212300410403 ; and Medical Education Research Project of Henan Province , No. Wjlx2021334 .
Institutional review board statement: The study was reviewed and approved by the Medical Ethics Committee of Henan Cancer Hospital (approval number: 2017002).
Institutional animal care and use committee statement: All procedures involving animals were reviewed and approved by the Animal Experiment Ethics Committee of Hubei Provincial Center for Disease Control and Prevention (approval number: 202310157).
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Data sharing statement: The datasets generated and/or analyzed in the current study are available from the corresponding author upon reasonable request.
ARRIVE guidelines statement: The authors have read the ARRIVE guidelines, and the manuscript was prepared and revised according to the ARRIVE guidelines.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Hai-Liang Li, MD, Chief Doctor, Department of Minimal Invasive Intervention, The Affiliated Cancer Hospital of Zhengzhou University, Henan Cancer Hospital, No. 127 Dongming Road, Zhengzhou 450003, Henan Province, China. lihailianggy@163.com
Received: March 6, 2024
Revised: May 3, 2024
Accepted: May 17, 2024
Published online: July 15, 2024
Processing time: 127 Days and 19.4 Hours
Revised: May 3, 2024
Accepted: May 17, 2024
Published online: July 15, 2024
Processing time: 127 Days and 19.4 Hours
Core Tip
Core Tip: This study revealed that the combination of transcatheter arterial chemoembolization and donafinib or lenvatinib may be relatively beneficial in improving the immune suppression status of patients and inducing relatively robust anti-tumor immune responses. In addition, certain immune cells and protein molecules are significantly correlated with the prognosis of patients. The study results provide patients with reference for their selection of combination therapy strategies and help them predict their clinical prognosis.