Basic Study
Copyright ©The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Oncol. Jul 15, 2024; 16(7): 3241-3255
Published online Jul 15, 2024. doi: 10.4251/wjgo.v16.i7.3241
RBM5 suppresses proliferation, metastasis and glycolysis of colorectal cancer cells via stabilizing phosphatase and tensin homolog mRNA
Chu-Xiang Wang, Feng Liu, Yi Wang
Chu-Xiang Wang, Department of Anorectal Surgery, The Affiliated Hospital of Dalian Medical University, Dalian 116000, Liaoning Province, China
Feng Liu, Department of Scientific Research, Beijing Fresta Technologies Co, Ltd., Beijing 100176, China
Yi Wang, Department of VIP Medical Services, National Cancer Center, National Clinical Research Center for Cancer, Cancer Hospital Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China
Author contributions: Wang CX and Wang Y designed the study; Wang CX, Liu F, and Wang Y carried out experiments; Liu F and Wang Y analyzed experimental results; Wang CX was a major contributor in writing the manuscript; and all authors reviewed and approved the manuscript.
Institutional animal care and use committee statement: Animal experiments were executed in accordance with the Animal Care and Use Committee of Beijing Viewsolid Biotechnology Co. LTD (Approval No. VS2126A00176).
Conflict-of-interest statement: All authors have nothing to disclose.
Data sharing statement: The authors confirm that the data supporting the findings of this study are available within the article.
ARRIVE guidelines statement: The authors have read the ARRIVE Guidelines, and the manuscript was prepared and revised according to the ARRIVE Guidelines.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Yi Wang, MD, Associate Chief Physician, Department of VIP Medical Services, National Cancer Center, National Clinical Research Center for Cancer, Cancer Hospital Chinese Academy of Medical Sciences and Peking Union Medical College, No. 17 Panjiayuan Nanli, Chaoyang District, Beijing 100021, China. dr_wangyi1018@163.com
Received: February 29, 2024
Revised: May 7, 2024
Accepted: May 24, 2024
Published online: July 15, 2024
Processing time: 134 Days and 13.3 Hours
Core Tip

Core Tip: RNA binding motif 5 (RBM5) exhibited low expression in colorectal cancer (CRC) tissues and cells. RBM5 retarded tumorigenesis and metastasis of CRC in vitro and in vivo. In terms of mechanism, RBM5 overexpression-induced tumor inhibition of CRC was partially mediated by the phosphatase and tensin homolog/phosphoinositide 3-kinase/anti-protein kinase pathway. These findings extend our knowledge of the link between RBM5 and CRC, shedding light on the mechanisms how RBM5 impair CRC tumorigenesis.