Aldehyde dehydrogenase 2 family member repression promotes colorectal cancer progression by JNK/p38 MAPK pathways-mediated apoptosis and DNA damage

doi:10.4251/wjgo.v16.i7.3230

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World Journal of Gastrointestinal Oncology

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1948-5204

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Basic Study

World J Gastrointest Oncol. Jul 15, 2024; 16(7): 3230-3240
Published online Jul 15, 2024. doi: 10.4251/wjgo.v16.i7.3230

Aldehyde dehydrogenase 2 family member repression promotes colorectal cancer progression by JNK/p38 MAPK pathways-mediated apoptosis and DNA damage

Miao Yu, Qian Chen, Yi-Ping Lu

Miao Yu, Yi-Ping Lu, Department of Surgical Oncology, Beijing Hospital of Traditional Chinese Medicine, Capital Medical University, Beijing 100010, China

Qian Chen, Clinical School of Traditional Chinese Medicine, Capital Medical University, Beijing 100010, China

Author contributions: Yu M, Lu YP designed the study; Chen Q and Lu YP collected and analyzed the data; Yu M wrote the manuscript. All authors reviewed and approved the final manuscript.

Supported by Beijing Municipal Hospital Research and Cultivation Program Project, No. PZ2022008.

Institutional animal care and use committee statement: All animal experiments were approved by the Animal Ethics Committee of Beijing Viewsolid Biotechnology Co. LTD (VS2126A00173).

Conflict-of-interest statement: All authors have nothing to disclose.

Data sharing statement: The authors confirm that the data supporting the findings of this study are available within the article.

ARRIVE guidelines statement: The authors have read the ARRIVE Guidelines, and the manuscript was prepared and revised according to the ARRIVE Guidelines.

Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/

Corresponding author: Yi-Ping Lu, MM, Chief Physician, Department of Surgical Oncology, Beijing Hospital of Traditional Chinese Medicine, Capital Medical University, No. 23 Art Museum Back Street, Dongcheng District, Beijing 100010, China. 15210712026@163.com

Received: February 23, 2024
Revised: April 29, 2024
Accepted: May 17, 2024
Published online: July 15, 2024
Processing time: 140 Days and 6 Hours

Core Tip

Core Tip: This work demonstrated that a (ALDH2) repression caused the accumulation of acetaldehyde, inducing cell apoptosis and DNA damage by means of activating the JNK/p38 MAPK signaling pathway in colorectal cancer (CRC). ALDH2 is utilized as a therapeutic target for reversing patients with CRC.