Weiwei Decoction alleviates gastric intestinal metaplasia through the olfactomedin 4/nucleotide-binding oligomerization domain 1/caudal-type homeobox gene 2 signaling pathway

doi:10.4251/wjgo.v16.i7.3211

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World Journal of Gastrointestinal Oncology

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1948-5204

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastrointest Oncol. Jul 15, 2024; 16(7): 3211-3229
Published online Jul 15, 2024. doi: 10.4251/wjgo.v16.i7.3211

Weiwei Decoction alleviates gastric intestinal metaplasia through the olfactomedin 4/nucleotide-binding oligomerization domain 1/caudal-type homeobox gene 2 signaling pathway

Di-Shu Zhou, Wei-Jian Zhang, Shu-Ya Song, Xin-Xin Hong, Wei-Qin Yang, Juan-Juan Li, Jian-Qu Xu, Jian-Yuan Kang, Tian-Tian Cai, Yi-Fei Xu, Shao-Ju Guo, Hua-Feng Pan, Hai-Wen Li

Di-Shu Zhou, Wei-Jian Zhang, Xin-Xin Hong, Juan-Juan Li, Jian-Qu Xu, Jian-Yuan Kang, Tian-Tian Cai, Yi-Fei Xu, Shao-Ju Guo, Hai-Wen Li, Shenzhen Traditional Chinese Medicine Hospital, The Fourth Clinical Medical College of Guangzhou University of Chinese Medicine, Shenzhen 518033, Guangdong Province, China

Di-Shu Zhou, Wei-Jian Zhang, Shu-Ya Song, Hua-Feng Pan, Science and Technology Innovation Center, Guangzhou University of Chinese Medicine, Guangzhou 510405, Guangdong Province, China

Wei-Qin Yang, Department of Chinese Medicine, The Eight Affiliated Hospital, Sun Yat-Sen University, Shenzhen 518033, Guangdong Province, China

Author contributions: Zhou DS, Zhang WJ, and Song SY wrote the original draft, designed and conducted the experiment; Hong XX, Yang WQ, and Li JJ edited the manuscript and analyzed the data; Xu JQ, Kang JY, Cai TT, and Xu YF edited the manuscript; Guo SJ and Pan HF reviewed the manuscript and administered the project; Li HW reviewed the manuscript, designed the research study, and administered the project; and all authors have read and approved the final manuscript.

Supported by National Natural Science Foundation of China, No. 82104747 and No. 82305133; Basic and Applied Basic Research Foundation of Guangdong Province, China, No. 2020A1515110947; General Project of Shenzhen Science and Technology Innovation Commission, No. JCYJ20230807094659030, No. JCYJ20230807094805012, No. JCYJ20210324111602007, and No. JCYJ20220531091815034; and the Scientific Research Project of Guangdong Provincial Bureau of Traditional Chinese Medicine, No. 20221349.

Institutional review board statement: The study was reviewed and approved by the Institutional Review Board at Guangzhou University of Chinese Medicine (No. 20211105008) and Shenzhen Traditional Chinese Medicine Hospital (No. K2022-011-02).

Institutional animal care and use committee statement: All procedures involving animals were reviewed and approved by the Institutional Animal Care and Use Committee of the Center of Science and Technology Innovation, Guangzhou University of Chinese Medicine (No. 20211105008).

Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.

Data sharing statement: No additional data are available.

ARRIVE guidelines statement: The authors have read the ARRIVE guidelines, and the manuscript was prepared and revised according to the ARRIVE guidelines.

Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/

Corresponding author: Hai-Wen Li, MD, Attending Doctor, Shenzhen Traditional Chinese Medicine Hospital, The Fourth Clinical Medical College of Guangzhou University of Chinese Medicine, No. 1 Fuhua Road, Futian District, Shenzhen 518033, Guangdong Province, China. 370062941@qq.com

Received: February 15, 2024
Revised: April 25, 2024
Accepted: May 11, 2024
Published online: July 15, 2024
Processing time: 148 Days and 11 Hours

Core Tip

Core Tip: Gastric intestinal metaplasia (IM) is a precancerous lesion that is associated with an elevated risk of gastric carcinogenesis. Weiwei Decoction (WWD) is a traditional Chinese herbal formula derived from Sijunzi Decoction that has been utilized to treat gastric disease for thousands of years. Nowadays, WWD is widely employed in clinical for treating IM. Previous studies suggested the potential involvement of the olfactomedin 4 (OLFM4)/nucleotide-binding oligomerization domain 1 (NOD1)/caudal-type homeobox gene 2 (CDX2) pathway in IM regulation. In this study, we preliminarily validated the pivotal role of the OLFM4/NOD1/CDX2 signaling pathway in regulating gastric IM. Focusing on this pathway, our investigation centered on the therapeutic effects of WWD against gastric IM.