Meng XY, Yang D, Zhang B, Zhang T, Zheng ZC, Zhao Y. Glycolysis-related five-gene signature correlates with prognosis and immune infiltration in gastric cancer. World J Gastrointest Oncol 2024; 16(7): 3097-3117 [DOI: 10.4251/wjgo.v16.i7.3097]
Corresponding Author of This Article
Yan Zhao, MD, Doctor, Department of Gastric Surgery, Cancer Hospital of China Medical University/Liaoning Cancer Hospital & Institute/The Liaoning Provincial Key Laboratory of Interdisciplinary Research on Gastrointestinal Tumor Combining Medicine with Engineering, No. 44 Xiaoheyan Road, Dadong District, Shenyang 110042, Liaoning Province, China. doctorzhaoyan@126.com
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Clinical and Translational Research
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Gastrointest Oncol. Jul 15, 2024; 16(7): 3097-3117 Published online Jul 15, 2024. doi: 10.4251/wjgo.v16.i7.3097
Glycolysis-related five-gene signature correlates with prognosis and immune infiltration in gastric cancer
Xiang-Yu Meng, Dong Yang, Bao Zhang, Tao Zhang, Zhi-Chao Zheng, Yan Zhao
Xiang-Yu Meng, Dong Yang, Bao Zhang, Tao Zhang, Zhi-Chao Zheng, Yan Zhao, Department of Gastric Surgery, Cancer Hospital of China Medical University/Liaoning Cancer Hospital & Institute/The Liaoning Provincial Key Laboratory of Interdisciplinary Research on Gastrointestinal Tumor Combining Medicine with Engineering, Shenyang 110042, Liaoning Province, China
Author contributions: Meng XY and Zhao Y contributed to the study design; Meng XY, Yang D, and Zhang B participated in the data analysis, algorithms, and statistical analysis; Zhang T and Zhao Y were involved in the quality control of data and algorithms, and financial support; Meng XY prepared the manuscript; and all authors contributed to the manuscript editing and review.
Supported byTraining Program of the National Natural Science Foundation of China, No. 2021-ZLLH-05; National Cancer Center Climbing Fund, No. NCC201906B02; Shenyang Municipal Science and Technology Public Health Research and Development Special Project, No. 21-172-9-03 and No. 22-321-33-53; and Dalian University of Technology-Liaoning Cancer Hospital Medical Engineering Cross-Union Fund, No. LD202309.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Yan Zhao, MD, Doctor, Department of Gastric Surgery, Cancer Hospital of China Medical University/Liaoning Cancer Hospital & Institute/The Liaoning Provincial Key Laboratory of Interdisciplinary Research on Gastrointestinal Tumor Combining Medicine with Engineering, No. 44 Xiaoheyan Road, Dadong District, Shenyang 110042, Liaoning Province, China. doctorzhaoyan@126.com
Received: April 9, 2024 Revised: May 14, 2024 Accepted: June 13, 2024 Published online: July 15, 2024 Processing time: 94 Days and 7.1 Hours
Core Tip
Core Tip: A five-gene signature consisting of syndecan 2, versican, malic enzyme 1, pyruvate carboxylase, and SRY-box transcription factor 9 was constructed. Based on their risk scores, the patients were stratified into high- or low-glycolysis groups. The patients with high glycolysis were significantly poorer. The high-glycolysis patients revealed dysregulation of pancreas beta cells and estrogen late pathways, while low-glycolysis patients showed associations with Myc targets, oxidative phosphorylation, mechanistic target of rapamycin complex 1 signaling, and G2M checkpoint pathways. A significant correlation between different glycolysis statuses and multiple immune cell infiltrations was observed. The high glycolysis status was associated with lower tumor mutational burden, higher incidence of microsatellite instability-high, as well as reduced chemosensitivity among gastric cancer patients.
