Clinical and Translational Research
Copyright ©The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Oncol. Jul 15, 2024; 16(7): 3069-3081
Published online Jul 15, 2024. doi: 10.4251/wjgo.v16.i7.3069
Prognostic significance of exportin-5 in hepatocellular carcinoma
Hao Li, Fei Li, Bo-Shen Wang, Bao-Li Zhu
Hao Li, Fei Li, Bo-Shen Wang, Bao-Li Zhu, Key Laboratory of Environmental Medicine Engineering of Ministry of Education, Southeast University, Nanjing 210000, Jiangsu Province, China
Hao Li, Fei Li, Bo-Shen Wang, Bao-Li Zhu, Institute of Occupational Disease Prevention, Jiangsu Provincial Center for Disease Control and Prevention, Nanjing 210000, Jiangsu Province, China
Bao-Li Zhu, Committee, Jiangsu Preventive Medical Association, Nanjing 210000, Jiangsu Province, China
Bao-Li Zhu, Center for Global Health, Nanjing Medical University, Nanjing 210000, Jiangsu Province, China
Bao-Li Zhu, Public Health Sector, Jiangsu Province Engineering Research Center Jiangsu Province Engineering Research Center of Health Emergency, Nanjing 210000, Jiangsu Province, China
Co-first authors: Hao Li and Fei Li.
Co-corresponding authors: Bo-Shen Wang and Bao-Li Zhu.
Author contributions: Li H and Wang BS designed the research study; Li H, Li F, and Wang BS performed the research; Zhu BL contributed new resources and supervision; Li H and Li F analyzed the data and wrote the manuscript; and all authors have read and approved the final manuscript. Li H and Li F contributed equally to this work as co-first authors; Wang BS and Zhu BL contributed equally to this work as co-corresponding authors. The reasons for designating Wang BS and Zhu BL as co-corresponding authors are that they provide comparable research resources and writing guidance.
Supported by the Scientific Research Project of Jiangsu Health Committee, No. M2022083; Natural Science Foundation of Jiangsu Province, No. BK20230742; Open Project of Key Laboratory of Environmental Medicine Engineering of Ministry of Education, No. 2022EME001; and Laboratory of Jiangsu Provincial Medical Key Discipline, No. ZDXK202249.
Conflict-of-interest statement: All the authors report having no relevant conflicts of interest for this article.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Bao-Li Zhu, Doctor, Associate Chief Physician, Chairman, Professor, Institute of Occupational Disease Prevention, Jiangsu Provincial Center for Disease Control and Prevention, No. 172 Jiangsu Road, Nanjing 210000, Jiangsu Province, China. zhublcdc@sina.com
Received: April 5, 2024
Revised: May 5, 2024
Accepted: May 22, 2024
Published online: July 15, 2024
Processing time: 97 Days and 19.6 Hours
Core Tip

Core Tip: This study reveals the pivotal role of exportin-5 (XPO5), a miRNA transport protein, in the progression and prognosis of hepatocellular carcinoma (HCC). Bioinformatic databases and in vitro assays demonstrated that XPO5 expression was upregulated in HCC tissues, correlating with aggressive tumor features and poor patient outcomes. Furthermore, XPO5 levels influenced immune cell behavior, particularly in T cells and macrophages, suggesting its potential as a target for immunotherapy. This study suggests that XPO5 could be used as a biomarker for the prognosis of HCC and as a novel therapeutic target.