Clinical and Translational Research
Copyright ©The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Oncol. Jul 15, 2024; 16(7): 3011-3031
Published online Jul 15, 2024. doi: 10.4251/wjgo.v16.i7.3011
Adipocytes impact on gastric cancer progression: Prognostic insights and molecular features
Jia-Rong Shang, Jin Zhu, Lu Bai, Delida Kulabiek, Xiao-Xue Zhai, Xia Zheng, Jun Qian
Jia-Rong Shang, Jin Zhu, Lu Bai, Delida Kulabiek, Xiao-Xue Zhai, Xia Zheng, Jun Qian, Department of Oncology, Jiangsu Province Hospital of Chinese Medicine, The Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing 210000, Jiangsu Province, China
Co-corresponding authors: Xia Zheng and Jun Qian.
Author contributions: Shang JR, Zhu J, Bai L, Kulabiek D, and Zhai XX collected, analyzed, and interpreted the data; Shang JR and Zhu J designed the research study and drafted the manuscript; Zheng X and Qian J provided guidance and support throughout the research process, assisted in data collection and analysis, and participated in manuscript revision and editing; All authors read and approved the final manuscript. Zheng X and Qian J are designated as co-corresponding authors based on their equal contributions to the conception, design, and execution of the research project, illustrating their shared responsibility in the development and implementation of the study. They collaborated closely in the acquisition, analysis, and interpretation of data, ensuring a comprehensive and rigorous evaluation of the results. Both authors actively participated in drafting and critically revising the manuscript, providing intellectual input, and approving the final version for submission. They jointly supervised the research, overseeing various aspects of the project to guarantee its integrity and accuracy. Their collaborative efforts and equal contributions underscore the significance of designating them as co-corresponding authors.
Supported by National Traditional Chinese Medicine Inheritance and Innovation Platform Construction Project by National Administration of Traditional Chinese Medicine, No. Y2020CX57; Jiangsu Provincial Administration of Traditional Chinese Medicine, No. MS2023014; and Jiangsu Graduate Student Research and Practice Innovation Program, No. SJCX23_0799.
Conflict-of-interest statement: All authors report no relevant conflicts of interest for this article.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Jun Qian, Doctor, MD, Chief Physician, Doctor, Professor, Department of Oncology, Jiangsu Province Hospital of Chinese Medicine, The Affiliated Hospital of Nanjing University of Chinese Medicine, No. 155 Hanzhong Road, Qinhuai District, Nanjing 210000, Jiangsu Province, China. jun_qian@njucm.edu.cn
Received: February 17, 2024
Revised: March 17, 2024
Accepted: May 28, 2024
Published online: July 15, 2024
Processing time: 146 Days and 2.4 Hours
Core Tip

Core Tip: Adipocytes within tumor tissue [cancer-associated adipocytes (CAA)] play a crucial role in gastric cancer (GC) progression and patient prognosis. This study confirmed that increased CAA expression correlated with adverse GC outcomes, independent of pathological features but potentially linked to patient age. A prognostic model based on key factors offered high accuracy for clinical decisions. Genes like ADH1B, SFRP1, PLAC9, and FABP4 showed diagnostic and prognostic promise with high CAA expression. Immune analysis revealed reduced immune cells in high CAA GC, suggesting increased tumor aggressiveness. These findings underscore the significance of adipocytes in GC, offering potential biomarkers for future diagnostics and therapeutics.