Systematic Reviews
Copyright ©The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Oncol. Jun 15, 2024; 16(6): 2781-2792
Published online Jun 15, 2024. doi: 10.4251/wjgo.v16.i6.2781
Ferroptosis regulating lipid peroxidation metabolism in the occurrence and development of gastric cancer
Lan-Mei Wang, Wei-Wei Zhang, Ying-Yang Qiu, Fang Wang
Lan-Mei Wang, Department of Clinical Laboratory, Anqiu People's Hospital, Weifang 262123, Shandong Province, China
Wei-Wei Zhang, Department of Gastroenterology, Feicheng People's Hospital, Tai’an 271600, Shandong Province, China
Ying-Yang Qiu, Yong Loo Lin School of Medicine, National University of Singapore, 119077, Singapore
Fang Wang, Department of Gastroenterology, Central Hospital Affiliated to Shandong First Medical University, Jinan 250013, Shandong Province, China
Author contributions: Wang LM wrote the manuscript; Zhang WW and Qiu YY collected the data and Draw diagrams; Wang F is responsible for monitoring research progress and guiding revisions; all authors reviewed, edited, and approved the final manuscript and revised it critically for important intellectual content, gave final approval of the version to be published, and agreed to be accountable for all aspects of the work.
Conflict-of-interest statement: The authors declare no conflict of interest.
PRISMA 2009 Checklist statement: The authors have read the PRISMA 2009 Checklist, and the manuscript was prepared and revised according to the PRISMA 2009 Checklist.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Fang Wang, MM, Doctor, Department of Gastroenterology, Central Hospital Affiliated to Shandong First Medical University, No. 105 Jiefang Road, Jinan 250013, Shandong Province, China. wangfangys010@163.com
Received: January 16, 2024
Revised: March 6, 2024
Accepted: April 10, 2024
Published online: June 15, 2024
Processing time: 150 Days and 20.8 Hours
Core Tip

Core Tip: As a highly aggressive tumor, the pathophysiological mechanism of gastric cancer has attracted much attention. In recent years, factors such as ferroptosis regulation, lipid peroxidation, and metabolic abnormalities have emerged in the study of gastric cancer, providing a new perspective for understanding the development of gastric cancer. Ferroptosis regulation, lipid peroxidation, and metabolic abnormalities play important roles in the occurrence and development of gastric cancer. The regulation of ferroptosis is involved in apoptosis and necrosis, affecting cell survival and death.