Kong S, Xu YH, Zheng M, Ju SQ, Shi HC. Circ_0004592: An auxiliary diagnostic biomarker for gastric cancer. World J Gastrointest Oncol 2024; 16(6): 2757-2768 [DOI: 10.4251/wjgo.v16.i6.2757]
Corresponding Author of This Article
Shao-Qing Ju, DPhil, Professor, Department of Laboratory Medicine, The Affiliated Hospital of Nantong University, No. 20 Xisi Road, Nantong 226001, Jiangsu Province, China. mucunmeishan1130@qq.com
Research Domain of This Article
Medical Laboratory Technology
Article-Type of This Article
Basic Study
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Gastrointest Oncol. Jun 15, 2024; 16(6): 2757-2768 Published online Jun 15, 2024. doi: 10.4251/wjgo.v16.i6.2757
Circ_0004592: An auxiliary diagnostic biomarker for gastric cancer
Shan Kong, Yan-Hua Xu, Ming Zheng, Shao-Qing Ju, Heng-Chuan Shi
Shan Kong, Heng-Chuan Shi, Department of Laboratory Medicine, Jiangsu Province Official Hospital, Nanjing 210000, Jiangsu Province, China
Yan-Hua Xu, Department of Laboratory Medicine, Northern Jiangsu People’s Hospital, Yangzhou 225000, Jiangsu Province, China
Ming Zheng, Shao-Qing Ju, Department of Laboratory Medicine, The Affiliated Hospital of Nantong University, Nantong 226001, Jiangsu Province, China
Co-first authors: Shan Kong and Yan-Hua Xu.
Co-corresponding authors: Shao-Qing Ju and Heng-Chuan Shi.
Author contributions: Kong S and Xu YH collected the related data for the manuscript and drafted it; Zheng M collected samples; Ju SQ participated in the design of the research; Shi HC helped to draft and modify the manuscript; and all authors read and approved the final manuscript.
Supported bythe Jiangsu Province Laboratory Medical Research Special Fund Project, No. SYH-3201160-0061(2023008).
Institutional review board statement: This study was reviewed and approved by the Ethics Committee of the Affiliated Hospital of Nantong University (Approval No. 2020-L038).
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Data sharing statement: All data and materials are available from the corresponding author.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Shao-Qing Ju, DPhil, Professor, Department of Laboratory Medicine, The Affiliated Hospital of Nantong University, No. 20 Xisi Road, Nantong 226001, Jiangsu Province, China. mucunmeishan1130@qq.com
Received: January 29, 2024 Revised: March 12, 2024 Accepted: April 12, 2024 Published online: June 15, 2024 Processing time: 137 Days and 9.8 Hours
Core Tip
Core Tip: Circ_0004592 was significantly overexpressed in gastric cancer (GC) tissues and plasma. Reverse transcription and real-time fluorescent quantitative polymerase chain reaction was validated as a robust approach for the detection of circ_0004592. The expression level of circ_0004592 in the plasma of patients with precancerous lesions was increased relative to that in healthy controls, suggesting that plasma circ_0004592 may serve as an early diagnostic biomarker. Further, its levels in plasma decreased following surgical resection of gastric tumors. High circ_0004592 expression was associated with the histological type, depth of tumor invasion, and lymph node metastasis of GC. These observations highlight the potential of circ_0004592 as a valuable diagnostic and prognostic biomarker.
