Basic Study
Copyright ©The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Oncol. Jun 15, 2024; 16(6): 2716-2726
Published online Jun 15, 2024. doi: 10.4251/wjgo.v16.i6.2716
Sm-like 5 knockdown inhibits proliferation and promotes apoptosis of colon cancer cells by upregulating p53, CDKN1A and TNFRSF10B
Cai-Jing Mo, Xiao-Yuan Deng, Ru-Lan Ma, Kun Zhu, Lei Shi, Kang Li
Cai-Jing Mo, Xiao-Yuan Deng, Ru-Lan Ma, Kun Zhu, Kang Li, Department of Surgical Oncology, The First Affiliated Hospital of Xi’an Jiaotong University, Xi’an 710061, Shaanxi Province, China
Lei Shi, Department of Infectious Diseases, The First Affiliated Hospital of Xi’an Jiaotong University, Xi’an 710061, Shaanxi Province, China
Co-corresponding authors: Lei Shi and Kang Li.
Author contributions: Li K and Shi L conceived and supervised the project; Mo CJ, Deng XY, Ma RL and Zhu K contributed to the experiments; Mo CJ and Ma RL wrote the manuscript. All the authors were involved in the study, critically revised the manuscript, and gave final approval.
Supported by Natural Science Basic Research Program of Shaanxi Province, No. 2021JM-256.
Institutional review board statement: This study does not involve any human subjects.
Institutional animal care and use committee statement: This study does not involve any animals.
Conflict-of-interest statement: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Data sharing statement: No additional data are available.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Kang Li, MD, Doctor, Department of Surgical Oncology, The First Affiliated Hospital of Xi’an Jiaotong University, No. 277 Yanta West Road, Yanta District, Xi’an 710061, Shaanxi Province, China. healthlee@xjtu.edu.cn
Received: December 27, 2023
Revised: March 18, 2024
Accepted: April 15, 2024
Published online: June 15, 2024
Processing time: 170 Days and 10.5 Hours
Core Tip

Core Tip: Sm-like 5 (LSM5) was highly expressed in tumor tissue and cells of colon cancer. Our study indicated that knockdown of LSM5 had an anti-tumor effect in colon cancer by up-regulating p53, cyclin-dependent kinase inhibitor 1A and tumor necrosis factor receptor superfamily 10B, which providing an important insight on the role of LSM5 in colon cancer development.