Basic Study
Copyright ©The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Oncol. Jun 15, 2024; 16(6): 2683-2696
Published online Jun 15, 2024. doi: 10.4251/wjgo.v16.i6.2683
Action of circulating and infiltrating B cells in the immune microenvironment of colorectal cancer by single-cell sequencing analysis
Jing-Po Zhang, Bing-Zheng Yan, Jie Liu, Wei Wang
Jing-Po Zhang, Bing-Zheng Yan, Wei Wang, Department of Hepatobiliary and Pancreatic Surgery, First Hospital of Hebei Medical University, Shijiazhuang 050032, Hebei Province, China
Jie Liu, Department of Hepatobiliary Surgery, Hunan Provincial People’s Hospital, Changsha 410002, Hunan Province, China
Author contributions: Zhang JP wrote the manuscript; Yan BZ and Liu J collected the data; Wang W conceived and guided the study. All authors reviewed, edited, and approved the final manuscript and revised it critically for important intellectual content, gave final approval of the version to be published, and agreed to be accountable for all aspects of the work.
Institutional review board statement: The study was reviewed and approved by the Institutional Review Board at Hunan Provincial People`s Hospital.
Conflict-of-interest statement: The authors declare no conflicts of interest.
Data sharing statement: Technical appendix, statistical code, and dataset available from the corresponding author at email: 10707514@qq.com.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Wei Wang, MD, Doctor, Department of Hepatobiliary and Pancreatic Surgery, First Hospital of Hebei Medical University, No. 89 Donggang Road, Yuhua District, Shijiazhuang 050032, Hebei Province, China. 10707514@qq.com
Received: December 12, 2023
Revised: March 10, 2024
Accepted: April 9, 2024
Published online: June 15, 2024
Processing time: 185 Days and 13.1 Hours
Core Tip

Core Tip: To explore the role of circulating and infiltrating B cell subsets in the immune microenvironment of colorectal cancer (CRC), explore the potential driving mechanism of B cell development, analyze the interaction between B cells and other immune cells in the immune microenvironment and the functions of communication molecules, and search for possible regulatory pathways to promote the anti-tumor effects of B cells. The role of germinal center B cells in CRC tumor microenvironment is greatly enhanced, and its affinity to tumor antigen is enhanced by its significantly increased heavy chain mutation level.