Basic Study
Copyright ©The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Oncol. Jun 15, 2024; 16(6): 2673-2682
Published online Jun 15, 2024. doi: 10.4251/wjgo.v16.i6.2673
Comprehensive analysis of gene mutations and mismatch repair in Chinese colorectal cancer patients
Huang Chen, Rui-Ying Jiang, Zhan Hua, Xiao-Wei Wang, Xiao-Li Shi, Ye Wang, Qian-Qian Feng, Jie Luo, Wu Ning, Yan-Fen Shi, Da-Kui Zhang, Bei Wang, Jian-Zheng Jie, Ding-Rong Zhong
Huang Chen, Rui-Ying Jiang, Xiao-Wei Wang, Ye Wang, Qian-Qian Feng, Jie Luo, Yan-Fen Shi, Bei Wang, Ding-Rong Zhong, Department of Pathology, China-Japan Friendship Hospital, Beijing 100029, China
Zhan Hua, Wu Ning, Da-Kui Zhang, Jian-Zheng Jie, Department of Gastrointestinal Surgery, China-Japan Friendship Hospital, Beijing 100029, China
Xiao-Li Shi, Department of Scientific Research, Geneis, Beijing 100012, China
Author contributions: Jie JZ and Zhong DR conceived and coordinated the research; Chen H, Jiang RY, Wang Y, Feng QQ, Luo J, and Ning W collected data from patients; Chen H, Hua Z, and Wang XW analyzed data and wrote the manuscript; Shi XL, Ning W, Shi YF, Zhang DK, and Wang B revised the manuscript; and all authors read and approved the final version of the manuscript.
Supported by National High Level Hospital Clinical Research Funding, No. 2023-NHLHCRF-YYPPLC-TJ-03.
Institutional review board statement: This study was conducted in accordance with the ethical guidelines and regulations approved by the Ethics Committee of China-Japan Friendship Hospital (Approval No. QX2021-001-01).
Conflict-of-interest statement: Xiao-Li Shi is currently employed by Geneis Beijing Co. Ltd. The authors declare that this research was conducted in the absence of potential conflicts of interest.
Data sharing statement: No additional data are available.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Ding-Rong Zhong, MD, Chief Doctor, Department of Pathology, China-Japan Friendship Hospital, No. 2 Yinghuayuan, East Street, Chaoyang District, Beijing 100029, China. 748803069@qq.com
Received: December 4, 2023
Revised: February 23, 2024
Accepted: April 12, 2024
Published online: June 15, 2024
Processing time: 193 Days and 17 Hours
Core Tip

Core Tip: This study presents a comprehensive analysis of KRAS, NRAS, BRAF, PIK3CA mutations, and mismatch repair (MMR)/microsatellite instability status in 2271 Chinese patients with colorectal cancer (CRC). Key findings include mutation frequencies, their association with clinicopathological characteristics, and the influence of MMR deficiency. These findings have significant implications for the clinical management of CRC, providing a foundation for personalized therapy and precision medicine in CRC.