Meta-Analysis
Copyright ©The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Oncol. May 15, 2024; 16(5): 2168-2180
Published online May 15, 2024. doi: 10.4251/wjgo.v16.i5.2168
Association of complement components with risk of colorectal cancer: A systematic review and meta-analysis
Xiao-Lin Zhu, Lu Zhang, Su-Xia Qi
Xiao-Lin Zhu, Su-Xia Qi, Department of Gastroenterology, Qingdao Municipal Hospital, Qingdao 266071, Shandong Province, China
Lu Zhang, Department of Medical Administration, Qingdao Municipal Hospital, Qingdao 266071, Shandong Province, China
Author contributions: Zhu XL and Qi SX designed the project; Zhu XL and Zhang L performed the literature search, data acquisition, and data extraction, and supported the writing of the paper; Zhu XL performed the statistical analyses; all authors read and approved the final manuscript.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
PRISMA 2009 Checklist statement: The authors have read the PRISMA 2009 Checklist, and the manuscript was prepared and revised according to the PRISMA 2009 Checklist.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Su-Xia Qi, MA, Department of Gastroenterology, Qingdao Municipal Hospital, No. 5 Donghai Middle Road, Qingdao 266071, Shandong Province, China. qisuxia_0@163.com
Received: December 15, 2023
Peer-review started: December 15, 2023
First decision: December 22, 2023
Revised: January 11, 2024
Accepted: March 4, 2024
Article in press: March 4, 2024
Published online: May 15, 2024
Processing time: 145 Days and 23.7 Hours
Core Tip

Core Tip: This meta-analysis provides evidence emphasizing that increased levels of specific complement components are associated with a high risk of colorectal cancer (CRC). Compared with the healthy control group, protein levels of cluster of differentiation 46 (CD46), CD59, and component 1 (C1), and serum levels of C3 were significantly elevated in patients with CRC. Significantly, patients with pronounced expression of CD55 or CD59 have a higher incidence of lymph node metastasis. Nevertheless, these findings emphasize the need for methodologically rigorous studies with larger sample sizes to corroborate these preliminary conclusions.