Retrospective Study
Copyright ©The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Oncol. May 15, 2024; 16(5): 1869-1877
Published online May 15, 2024. doi: 10.4251/wjgo.v16.i5.1869
Clinical outcome and prognostic factors of T4N0M0 colon cancer after R0 resection: A retrospective study
Bang Liu, Zhao-Xiong Zhang, Xin-Yang Nie, Wei-Lin Sun, Yong-Jia Yan, Wei-Hua Fu
Bang Liu, Zhao-Xiong Zhang, Xin-Yang Nie, Wei-Lin Sun, Yong-Jia Yan, Wei-Hua Fu, Department of General Surgery, Tianjin Medical University General Hospital, Tianjin Medical University, Tianjin 300052, China
Co-first authors: Bang Liu and Zhao-Xiong Zhang.
Co-corresponding authors: Yong-Jia Yan and Wei-Hua Fu.
Author contributions: Liu B and Zhang ZX contributed equally to this work; Liu B, Zhang ZX, Yan YJ and Fu WH designed the research study; Liu B, Zhang ZX, Nie XY and Sun WL performed the research; Liu B and Nie XY contributed analytic tools; Liu B and Zhang ZX analyzed the data and wrote the manuscript; All authors have read and approve the final manuscript.
Supported by Health Science and Technology Project of Tianjin Health Commission, No. ZC20190; Tianjin Key Medical Discipline (Specialty) Construction Project, No. TJYXZDXK-005A; and Tianjin Medical University Clinical Research Fund, No. 22ZYYLCCG04.
Institutional review board statement: The study was reviewed and approved by The Ethical Committee of Tianjin Medical University General Hospital, No. IRB2023-WZ-205.
Informed consent statement: Informed oral consent was obtained from the patients for the release of clinical data involved in this study.
Conflict-of-interest statement: The authors have no conflicts of interest to declare.
Data sharing statement: Technical appendix, statistical code, and dataset available from the corresponding author at tjmughgs_fwh@163.com. Participants gave informed oral consent for data sharing.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Wei-Hua Fu, MD, PhD, Professor, Surgeon, Teacher, Department of General Surgery, Tianjin Medical University General Hospital, Tianjin Medical University, No. 154 Anshan Road, Tianjin 300052, China. tjmughgs_fwh@163.com
Received: January 15, 2024
Peer-review started: January 15, 2024
First decision: February 5, 2024
Revised: February 14, 2024
Accepted: March 28, 2024
Article in press: March 28, 2024
Published online: May 15, 2024
Processing time: 115 Days and 6.7 Hours
Core Tip

Core Tip: Paradoxically, patients with T4N0M0 (stage II, no lymph node metastasis) colon cancer have a worse prognosis than those with T2N1-2M0 (stage III). However, no previous report has addressed this issue. A total of 200 patients underwent radical surgery with pTNM “T4N0M0” were enrolled in this study. The clinical data and outcomes of the 200 patients were analyzed. We confirmed enterostomy, T stage, right hemicolon, irregular review, carbohydrate antigen 199 were independent risk factors of overall survival by using multivariate analysis. A nomogram model based on these factors was established to predict the prognosis of patients with T4N0M0 colon cancer.