Basic Study
Copyright ©The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Oncol. Apr 15, 2024; 16(4): 1437-1452
Published online Apr 15, 2024. doi: 10.4251/wjgo.v16.i4.1437
Curcumin inhibits the growth and invasion of gastric cancer by regulating long noncoding RNA AC022424.2
Bin-Sheng Wang, Chen-Li Zhang, Xiang Cui, Qiang Li, Lei Yang, Zhi-Yun He, Ze Yang, Miao-Miao Zeng, Nong Cao
Bin-Sheng Wang, Xiang Cui, Lei Yang, Zhi-Yun He, Ze Yang, Miao-Miao Zeng, Nong Cao, Department of General Surgery, First Hospital of Lanzhou University, Lanzhou 730000, Gansu Province, China
Chen-Li Zhang, School of Basic Medical Sciences, Lanzhou University, Lanzhou 730000, Gansu Province, China
Qiang Li, Third Department of General Surgery, First Hospital of Lanzhou University, Lanzhou 730000, Gansu Province, China
Author contributions: Wang BS, Cui X, and Zhang CL performed the experiments and image acquisition; Wang BS, Cui X, Zhang CL, Li Q, Yang Z, Yang L, and He ZY designed the study and wrote the manuscript; Wang BS, Yang Z, and Cao N edited the manuscript.
Supported by the Natural Science Foundation of Gansu Province, China, No. 20JR5RA356 and No. 22JR5RA511; and the Lanzhou City Chengguan District Science and Technology Planning Project, No. 2016-7-17.
Institutional review board statement: This study was approved by the Ethics Committee of the First Hospital of Lanzhou University.
Conflict-of-interest statement: The authors declare that they have no competing interests.
Data sharing statement: The datasets used and/or analyzed during this study are available from the corresponding author upon reasonable request.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non-Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Nong Cao, MD, Professor, Department of General Surgery, First Hospital of Lanzhou University, No. 1 Donggang West Road, Lanzhou 730000, Gansu Province, China. caonongldyy@126.com
Received: October 13, 2023
Peer-review started: October 13, 2023
First decision: December 8, 2023
Revised: December 19, 2023
Accepted: January 17, 2024
Article in press: January 17, 2024
Published online: April 15, 2024
Core Tip

Core Tip: We investigated the effects of curcumin on gastric cancer cells, and we found that curcumin inhibited gastric cancer cell growth and induced apoptosis via long noncoding RNA (lncRNA) AC022424.2. Furthermore, the AKT and mTOR signaling pathways were involved in the process. We validated the role of lncRNA AC022424.2 on clinical samples and found that lncRNA AC022424.2 is associated with lymph metastasis.