Retrospective Study
Copyright ©The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Oncol. Mar 15, 2024; 16(3): 798-809
Published online Mar 15, 2024. doi: 10.4251/wjgo.v16.i3.798
Combining prognostic value of serum carbohydrate antigen 19-9 and tumor size reduction ratio in pancreatic ductal adenocarcinoma
Dong-Qin Xia, Yong Zhou, Shuang Yang, Fang-Fei Li, Li-Ya Tian, Yan-Hua Li, Hai-Yan Xu, Cai-Zhi Xiao, Wei Wang
Dong-Qin Xia, Shuang Yang, Fang-Fei Li, Li-Ya Tian, Yan-Hua Li, Hai-Yan Xu, Cai-Zhi Xiao, Wei Wang, Oncology Treatment Center of Traditional Chinese Medicine, Chongqing University Cancer Hospital, Chongqing 400030, China
Yong Zhou, Department of Oncology, Chongqing Weisiteng Biotech Translational Research Institute, Chongqing 430039, China
Yong Zhou, Chongqing Key Laboratory on Big Data for Bio Intelligence, Chongqing University of Posts and Telecommunications, Chongqing 430065, China
Co-first authors: Dong-Qin Xia and Shuang Yang.
Co-corresponding authors: Cai-Zhi Xiao and Wei Wang.
Author contributions: All authors contributed to the study’s conception and design; Yang S, Li FF, Tian LY, Li YH, Xu HY, Xiao CZ performed data collection and analysis; Xia DQ, Zhou Y, and Wang W wrote the manuscript; Xia DQ, Zhou Y polished and revised the manuscript; Xiao CZ, Wang W performed supervision; Xiao CZ, Wang W performed project administration; All authors commented on previous versions of the manuscript and read and approved the final manuscript. Xia DQ and Yang S contributed equally to this work as co-first authors. Xiao CZ and Wang W contributed equally to this work as co-corresponding authors. The reasons for designating Xia DQ and Yang S as co-first authors, Xiao CZ and Wang W as co-corresponding authors are threefold. First, the research was performed as a collaborative effort, and the designation of co-first authors and co-corresponding authorship accurately reflects the distribution of responsibilities and burdens associated with the time and effort required to complete the study and the resultant paper. This also ensures effective communication and management of post-submission matters, ultimately enhancing the paper's quality and reliability. Second, the overall research team encompassed authors with a variety of expertise and skills from different fields, and the designation of co-first authors and co-corresponding authors best reflects this diversity. This also promotes the most comprehensive and in-depth examination of the research topic, ultimately enriching readers' understanding by offering various expert perspectives. Third, Xia DQ and Yang S, Xiao CZ and Wang W contributed efforts of equal substance throughout the research process. The choice of these researchers as co-first authors and co-corresponding authors acknowledges and respects this equal contribution, while recognizing the spirit of teamwork and collaboration of this study. In summary, we believe that designating Xia DQ and Yang S as co-first authors, Xiao CZ and Wang W as co-corresponding authors are fitting for our manuscript as it accurately reflects our team's collaborative spirit, equal contributions, and diversity.
Supported by Natural Science Foundation of Chongqing, China, No. cstc2021jcyj-msxmX0501; and Chongqing Medical Scientific Research Project (Joint Project of Chongqing Health Commission and Science and Technology Bureau), No. 2022QNXM074.
Institutional review board statement: The study was approved by the Ethics Committee of the Institutional Review Board of the Chongqing University Cancer Hospital. Written informed consent was waived owing to the retrospective and deidentified nature of the study.
Informed consent statement: The written informed consent was waived owing to the retrospective and deidentified nature of this study.
Conflict-of-interest statement: The authors who have taken part in this study have nothing to disclose.
Data sharing statement: No additional data are available.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Wei Wang, MD, PhD, Professor, Oncology Treatment Center of Traditional Chinese Medicine, Chongqing University Cancer Hospital, No. 181 Hanyu Road, Chongqing 400030, China. zuiailicip@126.com
Received: September 19, 2023
Peer-review started: September 19, 2023
First decision: December 5, 2023
Revised: December 15, 2023
Accepted: January 27, 2024
Article in press: January 27, 2024
Published online: March 15, 2024
Processing time: 175 Days and 1.4 Hours
Core Tip

Core Tip: Our study demonstrated that post-neoadjuvant therapy (NAT) serum carbohydrate antigen 19-9 (CA19-9) level/pre-NAT serum CA19-9 level and post-NAT tumor size/pre-NAT tumor size were independent factors associated with overall survival for patients receiving NAT and subsequently surgical resection for pancreatic ductal adenocarcinoma.