Retrospective Study
Copyright ©The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Oncol. Mar 15, 2024; 16(3): 787-797
Published online Mar 15, 2024. doi: 10.4251/wjgo.v16.i3.787
High patatin like phospholipase domain containing 8 expression as a biomarker for poor prognosis of colorectal cancer
Peng-Yang Zhou, De-Xiang Zhu, Yi-Jiao Chen, Qing-Yang Feng, Yi-Hao Mao, Ao-Bo Zhuang, Jian-Min Xu
Peng-Yang Zhou, De-Xiang Zhu, Yi-Jiao Chen, Qing-Yang Feng, Yi-Hao Mao, Ao-Bo Zhuang, Jian-Min Xu, Department of General Surgery, Zhongshan Hospital Fudan University, Shanghai 200032, China
Author contributions: Zhou PY carried out the studies; Zhuang AB and Chen YJ participated in collecting data and drafted the manuscript; Mao YH and Feng QY performed statistical analysis and participated in its design; Zhu DX participated in acquisition, analysis, and interpretation of data and drafted the manuscript; all authors read and approved the final manuscript.
Institutional review board statement: This study was approved by the Clinical Research Ethics Committee of Zhongshan Hospital, Fudan University.
Informed consent statement: Informed consent was acquired from all patients of the primary cohort for the acquisition of clinical and pathological information and the use of surgical specimens.
Conflict-of-interest statement: The authors report having no relevant conflicts of interest for this article.
Data sharing statement: No additional data are available.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non-Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Jian-Min Xu, PhD, Professor, Surgeon, Department of General Surgery, Zhongshan Hospital Fudan University, No. 180 Fenglin Road, Shanghai 200032, China. xujmin@aliyun.com
Received: August 22, 2023
Peer-review started: August 22, 2023
First decision: November 21, 2023
Revised: December 19, 2023
Accepted: January 22, 2024
Article in press: January 22, 2024
Published online: March 15, 2024
Processing time: 203 Days and 2.7 Hours
Core Tip

Core Tip: Patatin like phospholipase domain containing 8 (PNPLA8) has been shown to be associated with a variety of cancers, but its role in the progression of colorectal cancer (CRC) is unclear. In this study, 751 consecutive CRC patients were retrospectively analyzed. The results of this study indicate that PNPLA8 is a new independent prognostic factor for CRC. High PNPLA8 expression in CRC leads to impaired survival. These findings suggest that PNPLA8 is a potential target for clinical CRC therapy, providing important insights to help personalize therapy for CRC patients.