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©The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Oncol. Dec 15, 2024; 16(12): 4766-4769
Published online Dec 15, 2024. doi: 10.4251/wjgo.v16.i12.4766
Published online Dec 15, 2024. doi: 10.4251/wjgo.v16.i12.4766
Current efficacy of hepatic arterial infusion chemotherapy in hepatocellular carcinoma
Douglas Dias E Silva, Department of Oncology, Hospital Israelita Albert Einstein, São Paulo 05652900, Sao Paulo, Brazil
Mitesh Borad, Division of Hematology-Oncology, Department of Medicine, Mayo Clinic Arizona, Mayo Clinic Cancer Center, Phoenix, AZ 85054, United States
Pedro Luiz Serrano Uson Junior, Center for Personalized Medicine, Hospital Israelita Albert Einstein, São Paulo 05652900, Sao Paulo, Brazil
Author contributions: Dias e Silva D, Borad M, and Uson Junior PLS wrote and revised the article, reviewed the literature, and approved the final version of the manuscript.
Conflict-of-interest statement: The authors declare no conflicts-of-interest.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Pedro Luiz Serrano Uson Junior, MD, Assistant Professor, Center for Personalized Medicine, Hospital Israelita Albert Einstein, Avenida Albert Einstein 627, São Paulo 05652900, Sao Paulo, Brazil. pedro.serrano@einstein.br
Received: July 21, 2024
Revised: August 28, 2024
Accepted: October 12, 2024
Published online: December 15, 2024
Processing time: 113 Days and 17.8 Hours
Revised: August 28, 2024
Accepted: October 12, 2024
Published online: December 15, 2024
Processing time: 113 Days and 17.8 Hours
Core Tip
Core Tip: This meta-analysis provides a valuable and comprehensive evaluation of hepatic arterial infusion chemotherapy (HAIC) and its combination therapies for advanced hepatocellular carcinoma. Compared to other treatments including transarterial chemoembolization, HAIC showed favorable outcomes including response rate and survival. Furthermore, based on the findings, combination of HAIC with antiangiogenics and even immune checkpoint inhibitors seems to improve efficacy when compared to HAIC alone.