Review
Copyright ©The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Oncol. Nov 15, 2024; 16(11): 4338-4353
Published online Nov 15, 2024. doi: 10.4251/wjgo.v16.i11.4338
Advances in the diagnosis and treatment of MET-variant digestive tract tumors
Chen Zhang, Hu-Ke Dong, Jian-Ming Gao, Qi-Qi Zeng, Jiang-Tao Qiu, Jia-Jia Wang
Chen Zhang, The First Department of Radiation Oncology, Lu’an Hospital of Traditional Chinese Medicine of Anhui Province, Lu’an 237000, Anhui Province, China
Hu-Ke Dong, The Fourth Department of Oncology, The First Affiliated Hospital of Anhui Medical University, Hefei 230000, Anhui Province, China
Jian-Ming Gao, The First Department of Oncology, The First Affiliated Hospital of Anhui University of Traditional Chinese Medicine, Hefei 230000, Anhui Province, China
Qi-Qi Zeng, Department of Gastroenterology, Nanjing University Affiliated Gulou Hospital, Nanjing 210008, Jiangsu Province, China
Jiang-Tao Qiu, Department of Gastrointestinal Surgery, Beijing Tsinghua Changgung Hospital, Beijing 100084, China
Jia-Jia Wang, Ultrasound of Medicine Department, The Second Affiliated Hospital of Anhui Medical University, Hefei 230601, Anhui Province, China
Co-first authors: Chen Zhang and Hu-Ke Dong.
Author contributions: Zhang C and Dong HK wrote the manuscript, they contributed equally to this study, and they are the co-first authors of this manuscript; Gao JM, Zeng QQ, and Qiu JT collected the data; Wang JJ guided the study. All authors reviewed, edited, and approved the final manuscript and revised it critically for important intellectual content, gave final approval of the version to be published, and agreed to be accountable for all aspects of the work.
Supported by 2023 Anhui Province Clinical Medical Research Transformation Project, No. 202304295107020016.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Jia-Jia Wang, PhD, Doctor, Ultrasound of Medicine Department, The Second Affiliated Hospital of Anhui Medical University, No. 678 Furong Road, Shushan District, Hefei 230601, Anhui Province, China. ahwangjiajia@163.com
Received: July 8, 2024
Revised: August 24, 2024
Accepted: September 10, 2024
Published online: November 15, 2024
Processing time: 109 Days and 4.5 Hours
Core Tip

Core Tip: Our study reviews the progress in the use of MET variation in the diagnosis and treatment of digestive tract tumors and discusses the molecular mechanism of MET variation and its role in the genesis and development of digestive tract tumors. The analysis focused on the potential of MET variants as diagnostic markers and therapeutic targets, covering the latest research results and clinical trial data for MET-based targeted therapies. This paper also summarizes the current challenges and future research directions, aiming to provide new ideas and references for improving the diagnostic accuracy and treatment effectiveness of MET-variant digestive tract tumors.