Yu HB, Jia KF, Wang XF, Li BY, Xin Q. Navigating the complex landscape of crawling-type gastric adenocarcinomas: Insights and implications for clinical practice. World J Gastrointest Oncol 2024; 16(11): 4309-4314 [PMID: PMC11551647 DOI: 10.4251/wjgo.v16.i11.4309]
Corresponding Author of This Article
Qi Xin, PhD, Associate Chief Physician, Department of Pathology, The Third Central Hospital of Tianjin, No. 83 Jintang Road, Tianjin 300170, China. xinqi19820204@126.com
Research Domain of This Article
Oncology
Article-Type of This Article
Editorial
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Hai-Bo Yu, Laboratory, The Second Hospital of Tianjin Medical University, Tianjin 300211, China
Ke-Feng Jia, Department of Radiology, Tianjin Third Central Hospital, Tianjin 300170, China
Xing-Fen Wang, Department of Pathology, The Second Hospital of Tianjin Medical University, Tianjin 300211, China
Bao-Yu Li, Department of Gastrointestinal Surgery, The Second Hospital of Tianjin Medical University, Tianjin 300211, China
Qi Xin, Department of Pathology, The Third Central Hospital of Tianjin, Tianjin 300170, China
Co-first authors: Hai-Bo Yu and Ke-Feng Jia.
Author contributions: Yu HB contributed to data collection; Wang XF evaluated the images; Xin Q contributed to the pathological analysis; Yu HB, Jia KF, and Li BY contributed to revision of the manuscript; All authors agreed to publication of the manuscript.
Supported byThe Third Central Hospital of Tianjin, No. 2019YNR3.
Conflict-of-interest statement: The authors declare that they have no conflict of interest.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Qi Xin, PhD, Associate Chief Physician, Department of Pathology, The Third Central Hospital of Tianjin, No. 83 Jintang Road, Tianjin 300170, China. xinqi19820204@126.com
Received: March 18, 2024 Revised: June 3, 2024 Accepted: June 26, 2024 Published online: November 15, 2024 Processing time: 221 Days and 7.7 Hours
Core Tip
Core Tip: Crawling-type gastric adenocarcinoma (CRA) is characterized by its elusive presentation and propensity for lateral expansion within the mucosal layer, posing significant challenges to early detection. This study emphasizes the need for a multidisciplinary approach to achieve accurate diagnosis and effective treatment. The findings reveal distinct molecular features of CRA including the notably increased mutation frequencies in the TP53 and RHOA genes, and the absence of HER2 amplification. These characteristics highlight the critical need for precision in diagnostic and therapeutic modalities. The objective is to augment clinical awareness, thereby facilitating prompt identification and efficient management of this subtype of gastric cancer.
