Editorial
Copyright ©The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Oncol. Nov 15, 2024; 16(11): 4300-4308
Published online Nov 15, 2024. doi: 10.4251/wjgo.v16.i11.4300
Molecular mechanisms underlying roles of long non-coding RNA small nucleolar RNA host gene 16 in digestive system cancers
Ting-Fang Yang, Xin-Rui Li, Mo-Wei Kong
Ting-Fang Yang, Department of Oncology, Guiqian International General Hospital, Guiyang 550018, Guizhou Province, China
Xin-Rui Li, Mo-Wei Kong, Department of Cardiology, Guiqian International General Hospital, Guiyang 550018, Guizhou Province, China
Co-first authors: Ting-Fang Yang and Xin-Rui Li.
Author contributions: Yang TF and Li XR contributed equally to this work as co-first authors; Kong MW provided crucial suggestions and guidance for manuscript writing; Yang TF wrote the manuscript; Li XR reviewed and revised the manuscript; and all authors read and approved the final manuscript.
Conflict-of-interest statement: The authors have no conflicts of interest to declare that are relevant to the content of this article.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Mo-Wei Kong, MD, Doctor, Department of Cardiology, Guiqian International General Hospital, No. 1 Dongfeng Avenue, Wudang District, Guiyang 550018, Guizhou Province, China. 1600181272@qq.com
Received: February 25, 2024
Revised: June 13, 2024
Accepted: July 2, 2024
Published online: November 15, 2024
Processing time: 242 Days and 21.5 Hours
Core Tip

Core Tip: The long non-coding RNA (lncRNA) small nucleolar RNA host gene 16 (SNHG16) plays a significant role in the development and progression of various digestive system cancers, including esophageal, liver, pancreatic, gastric, and colorectal cancers. It is involved in processes such as cell proliferation, migration, invasion, apoptosis, and chemoresistance. SNHG16 acts as a competing endogenous RNA, interacting with microRNAs and regulating target genes, and is associated with a poor prognosis in digestive system cancers. Its expression is influenced by transcription factors and its polymorphisms are linked to cancer susceptibility. SNHG16 has potential as a biomarker and therapeutic target for digestive system cancers.