Conversion therapy for unresectable hepatocellular carcinoma: Advances and challenges

doi:10.4251/wjgo.v16.i10.4289

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World Journal of Gastrointestinal Oncology

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1948-5204

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Letter to the Editor

World J Gastrointest Oncol. Oct 15, 2024; 16(10): 4289-4297
Published online Oct 15, 2024. doi: 10.4251/wjgo.v16.i10.4289

Conversion therapy for unresectable hepatocellular carcinoma: Advances and challenges

Yan-Fei He

Yan-Fei He, Department of Health Management Center, The Sixth Medical Center, Chinese People’s Liberation Army General Hospital, Beijing 100048, China

Author contributions: He YF designed the study, collected the data, reviewed the literature, drafted and revised the manuscript, and have read and approved the final manuscript.

Conflict-of-interest statement: The authors declare that they have no conflict of interest.

Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/

Corresponding author: Yan-Fei He, MD, Associate Chief Physician, Doctor, Department of Health Management Center, The Sixth Medical Center, Chinese People’s Liberation Army General Hospital, No. 6 Fucheng Road, Haidian District, Beijing 100048, China. heyanfeilc@163.com

Received: March 2, 2024
Revised: August 29, 2024
Accepted: September 5, 2024
Published online: October 15, 2024
Processing time: 208 Days and 6.4 Hours

Core Tip

Core Tip: This letter reviews recent advances in conversion therapy for hepatocellular carcinoma (HCC), comparatively describes the characteristics of different conversion programs, addresses current challenges in conversion therapy, highlights the complexity of conversion therapy for moderately advanced HCC, and emphasizes the importance of a multidisciplinary, team-based management model, and provides valuable insights into the treatment of unresectable HCC.