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©The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Oncol. Oct 15, 2024; 16(10): 4209-4231
Published online Oct 15, 2024. doi: 10.4251/wjgo.v16.i10.4209
Published online Oct 15, 2024. doi: 10.4251/wjgo.v16.i10.4209
Jianpi-Huatan-Huoxue-Anshen formula ameliorates gastrointestinal inflammation and microecological imbalance in chemotherapy-treated mice transplanted with H22 hepatocellular carcinoma
Ya-Nan Wang, Zheng Wang, Wen-Li Tang, Xue-Min Fu, Huai-Bang Li, Peng-Fei Li, Sheng-Yan Xi, Department of TCM, Xiang’an Hospital, School of Medicine, Xiamen University, Xiamen 361102, Fujian Province, China
Xiang-Yang Zhai, Faculty of Chinese Medicine and State Key Laboratory of Quality Research in Chinese Medicine, Macau University of Science and Technology, Macau 999078, China
Chun-Ling Gao, Department of Radiotherapy, Chenggong Hospital of Xiamen University, PLA 73rd Army Hospital, Xiamen 361003, Fujian Province, China
Sui-Cai Mi, Department of Oncology, Xiamen Hospital of Traditional Chinese Medicine, Xiamen 361015, Fujian Province, China
Li-Feng Yue, Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing 100700, China
Author contributions: Wang YN was responsible for methodology, data curation, and writing of the original draft; Zhai XY was responsible for methodology and validation; Wang Z was responsible for methodology and data curation; Gao CL, Mi CS, Tang WL, Fu XM, and Li HB were responsible for methodology; Yue LF was responsible for manuscript review & editing; Li PF was responsible for project administration; Xi SY was responsible for manuscript review & editing, funding acquisition, supervision, and project administration; all authors have read and agreed to the published version of the manuscript.
Supported by Natural Science Foundation of Xiamen , China, No. 3502Z20227171; the Young Investigator Research Program of Xiang’an Hospital of Xiamen University , No. XAH23005 ; the Traditional Chinese Medicine Foundation of Xiamen , No. XWZY-2023-0103 ; Natural Science Foundation of Fujian , China, No. 2018J01136; and National Natural Science Foundation of China , No. 81202659 .
Institutional animal care and use committee statement: All experimental steps of this experiment have been approved by the Animal Management Ethics Committee of Xiamen University (XMULAC-20170018).
Conflict-of-interest statement: The authors declare that there are no known competing financial interests or personal relationships among all authors of this article that could influence all studies reported in this article.
Data sharing statement: The data of this study are available from the corresponding author or any co-author on request.
ARRIVE guidelines statement: The authors have read the ARRIVE guidelines, and the manuscript was prepared and revised according to the ARRIVE guidelines.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Sheng-Yan Xi, Doctor, PhD, Associate Chief Physician, Associate Professor, Department of TCM, Xiang’an Hospital, School of Medicine, Xiamen University, No. 4221-122 Xiang’an Nan Road, Xiamen 361102, Fujian Province, China.
Received: April 7, 2024
Revised: August 6, 2024
Accepted: September 3, 2024
Published online: October 15, 2024
Processing time: 172 Days and 7.2 Hours
Revised: August 6, 2024
Accepted: September 3, 2024
Published online: October 15, 2024
Processing time: 172 Days and 7.2 Hours
Core Tip
Core Tip: Jianpi-Huatan-Huoxue-Anshen formula (Tzu-Chi cancer-antagonizing & life-protecting II decoction) down-regulates the NF-κB signaling pathway and the release of inflammatory factors, alleviates intestinal inflammation, improves intestinal morphology, reduces intestinal barrier damage, and maintains the dynamic balance of intestinal microecology. These results reveal the potential role and advantages of Chinese herbal compounds in improving the unbalanced microenvironment after cancer chemotherapy.