Retrospective Cohort Study
Copyright ©The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Oncol. Oct 15, 2024; 16(10): 4092-4103
Published online Oct 15, 2024. doi: 10.4251/wjgo.v16.i10.4092
Establishing prognostic models for intrahepatic cholangiocarcinoma based on immune cells
Zhuo-Ran Wang, Cun-Zhen Zhang, Zhan Ding, Yi-Zhuo Li, Jian-Hua Yin, Nan Li
Zhuo-Ran Wang, Cun-Zhen Zhang, Nan Li, Department of Hepatic Surgery I (Ward I) Shanghai Eastern Hepatobiliary Surgery Hospital, Navy Medical University, Shanghai 200433, China
Zhuo-Ran Wang, Zhan Ding, Jian-Hua Yin, Key Laboratory of Biological Defense, Ministry of Education, Navy Medical University, Shanghai 200433, China
Zhuo-Ran Wang, Zhan Ding, Jian-Hua Yin, Shanghai Key Laboratory of Medical Bioprotection, Navy Medical University, Shanghai 200433, China
Zhuo-Ran Wang, Zhan Ding, Jian-Hua Yin, Department of Epidemiology, Faculty of Navy Medicine, Navy Medical University, Shanghai 200433, China
Yi-Zhuo Li, Department of Oncology, 905 Hospital of People’s Liberation Army Navy, Shanghai 200050, China
Nan Li, Department of Hepatobiliary Surgery, The Second Affiliated Hospital, Wenzhou Medical University, Wenzhou 325000, Zhejiang Province, China
Co-first authors: Zhuo-Ran Wang and Cun-Zhen Zhang.
Co-corresponding authors: Jian-Hua Yin and Nan Li.
Author contributions: Li N and Yin JH designed the research; Wang ZR and Zhang CZ performed the research and contributed materials; Wang ZR, Ding Z and Li YZ analyzed the data; Wang ZR, Zhang CZ, and Li N wrote the paper; Yin JH obtained funding; all authors critically revised the manuscript for important intellectual content. All authors approved the final version of the article. Yin JH and Li N are designated as co-corresponding authors due to their significant contributions to this study. Professor Yin JH, from the Key Laboratory of Biological Defense (Ministry of Education) and the Shanghai Key Laboratory of Medical Bioprotection, also serves as a professor in the Department of Epidemiology at the Navy Medical University. His extensive expertise in immune cell research and their roles in the tumor microenvironment was pivotal in guiding the selection of immune markers and performing the data analysis, which formed the theoretical basis for the development of the prognostic models in this study. Professor Li N, an expert in hepatic surgery at the Department of Hepatic Surgery I, Shanghai Eastern Hepatobiliary Surgery Hospital, contributed his rich clinical experience in treating intrahepatic cholangiocarcinoma. He was responsible for the collection and follow-up of clinical data from patients, integrating this with immune cell analysis to facilitate the construction of the prognostic models. Their complementary expertise in basic immunological research and clinical practice made critical contributions to the success of this study and the translation of its findings into practical applications. Thus, they are appropriately designated as co-corresponding authors.
Supported by Program of Shanghai Academic Research Leader, No. 22XD1404800.
Institutional review board statement: This study was reviewed and approved by the Ethics Committee of Shanghai Eastern Hepatobiliary Surgery Hospital.
Informed consent statement: Signed informed consent was obtained from all participants in the study.
Conflict-of-interest statement: All the authors have nothing to disclose.
Data sharing statement: The data that support the findings can be found. The data were deposited into data repositories.
STROBE statement: The authors have read the STROBE Statement-checklist of items, and the manuscript was prepared and revised according to the STROBE Statement-checklist of items.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Nan Li, Doctor, PhD, Doctor, Department of Hepatic Surgery I (Ward I) Shanghai Eastern Hepatobiliary Surgery Hospital, Navy Medical University, No. 800 Xiangyin Road, Shanghai 200433, China. liparislisi@aliyun.com
Received: July 30, 2024
Revised: August 26, 2024
Accepted: September 6, 2024
Published online: October 15, 2024
Processing time: 58 Days and 9.6 Hours
Core Tip

Core Tip: We present a comprehensive study investigating the prognostic significance of immune cell infiltration and clinical parameters in patients with surgically resected intrahepatic cholangiocarcinoma (ICC). Our research elucidates the intricate interplay between immune cell composition within the tumor microenvironment and clinical outcomes in patients with ICC, offering valuable insights into the development of prognostic predictors and potential therapeutic strategies for this challenging disease.